Summary
The fate of fra(X) was followed after fusion of cells donated by a male fra(X) carrier with mouse A9 cells. Suppression of the fragile site was found in the hybrids as well as in human cells co-cultivated with mouse cells.
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References
Davidson R, O'Malley KA, Wheeler TB (1976) Polyethylene glycolinduced mammalian cell hybridisation: Effect of polyethylene glycol molecular weight and concentration. Somatic Cell Genet 2:271–280
Eberle G, Zankl H, Zankl M (1982) Cocultivation studies with cells of patients bearing fragile X chromosomes. Hum Genet 61:163–164
Glover TW (1981) FUdR induction of the X chromosome fragile site: Evidence for the mechanism of folic acid and thymidine inhibition. Am J Hum Genet 33:234–242
Hecht F, Jacky PB, Sutherland GP (1982) The fragile X chromosome: Current methods. Am J Med Genet 11:489–495
Herbst DS, Dunn HG, Dill FJ, Kalousek DK, Krywaniuk LW (1981) Further delineation of X-linked mental retardation. Hum Genet 58:366–372
Sperling K (1982) Complementation studies in human genetic disorders: Analysis of heterogeneity. Biol Zbl 101:745–762
Tommerup N, Poulsen H, Brøndum-Nielsen K (1981) 5-fluoro-2′-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation. J Med Genet 18:374–376
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Wegner, RD., Geiseler, B. & Sperling, K. Expression of fra(X)(q28) is Suppressed in man-mouse hybrid cells. Hum Genet 62, 353–354 (1982). https://doi.org/10.1007/BF00304555
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DOI: https://doi.org/10.1007/BF00304555