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Epistatic association and linkage analysis in human families

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Summary

A new method is given to test for phenotypic association using related individuals in pedigree analysis. It is also shown how an extension of this method allows analyses of genetic linkage in the presence of epistatic associations. A published pedigree with strong evidence for linkage between Lp and ESD is reanalyzed, resulting in a considerable drop of the lod score for linkage.

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Authors and Affiliations

  1. City Statistical Office, Napfgasse 6, CH-8001, Zürich, Switzerland

    Jurg Ott

  2. The New York Blood Center, 310 East 67 Street, 10021, New York, NY, USA

    Catherine T. Falk

Authors
  1. Jurg Ott
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  2. Catherine T. Falk
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Additional information

Dr. Falk is supported by a grant from the National Institutes of Health (GM 29177)

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Ott, J., Falk, C.T. Epistatic association and linkage analysis in human families. Hum Genet 62, 296–300 (1982). https://doi.org/10.1007/BF00304542

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