Summary
The metabolism of mucopolysaccharides (MPS) and glycoproteins in the rabbit skin was studied after painting with 7,12-Dimethylbenz(a)anthracene (DMBA).
The synthesis and turnover of MPS increased progressively in the early phases of treatment and remained at high values for the duration of the treatment.
Sialic acid-containing glycoproteins of fractions soluble and insoluble in saline had variations similar to those of MPS.
The data are related to the role attributed to the dermal changes during skin carcinogenesis.
Zusammenfassung
Nach Pinselung mit 7,12-Dimethylbenz[a]anthrazen (DMBA) wurde der Stoffwechsel von Mukopolysacchariden (MPS) und Glykoproteinen in Kaninchenhaut untersucht. Die Synthese und der Turnover von MPS wurde in den frühen Phasen der Behandlung zunehmend erhöht und blieb bei hohen Werten während der Dauer der Behandlung.
Sialinsäure enthaltende Glykoproteine aus in Kochsalzlösung löslichen und unlöslichen Fraktionen zeigten ähnliche Unterschiede wie die MPS.
Die Ergebnisse stehen in Beziehung zu der Rolle, die dermalen Änderungen während der Hautcarcinogenese zugeschrieben wird.
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Prodi, G., Ferreri, A.M., Rocchi, P. et al. Metabolism of complex carbohydrates of rabbit skin during treatment with 7,12-dimethylbenz(a)anthracence. Z. Krebsforsch. 81, 161–168 (1974). https://doi.org/10.1007/BF00304155
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DOI: https://doi.org/10.1007/BF00304155