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Calcium, magnesium and phosphorus in experimental tumors: effects of the age of the tumor

Calcium, Magnesium und Phosphor bei experimentellen Tumoren: Effekte auf Grund des Alters der Tumoren

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Summary

The calcium, magnesium and phosphorus contents of tissues from animals bearing experimental tumors were determined at different times of the tumor growth. In tumor, the ratio P/Ca increases sharply after transplantation as well as the ratio Mg/Ca does. After reaching a maximum both ratios decrease as the tumor grows further. There is a relationship between the 45Ca specific activity in tumor and the exchangeable calcium concentration in the same tissue. Both increase sharply with the growth in fast growing tumors and more gradually in the slow growing tumors. At the meantime the bone 45Ca specific activity decreases which is an indication of a probable increase in bone calcium resorption or of an inhibited absorption of calcium by bone. The steady increase of magnesium concentration during the period of higher growth rate points out a possible implication of this element in the high metabolic activity of the tumor.

Zusammenfassung

Der Calcium-, Magnesium- und Phosphorgehalt von Geweben tumortragender Tiere wurde zu verschiedenen Zeiten des Tumorwachstums bestimmt. In Tumoren steigt nach der Transplantation das Verhältnis P/Ca sowie das Verhältnis Mg/Ca steil an. Nachdem sie ein Maximum erreicht haben, sinken beide bei weiterem Tumorwachstum wieder ab.

Es besteht ein Zusammenhang zwischen der spezifischen Aktivität des 45Ca im Tumor und der austauschbaren Calciumkonzentration im selben Gewebe. Beide steigen mit dem Wachstum der schnell wachsenden Tumoren deutlich und bei langsam wachsenden Tumoren all-mählicher an. Gleichzeitig nimmt die spezifische Aktivität von 45Ca im Knochengewebe ab, was als Zeichen eines vermutlichen Anstiegs der Knochencalciumresorption oder einer gestörten Absorption von Calcium durch das Knochengewebe gelten kann.

Die stete Zunahme der Magnesiumkonzentration während der Phase der höheren Wachstumsrate weist auf eine mögliche Beteiligung dieses Elements an der größeren Stoffwechsel-Aktivität des Tumors hin.

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Abbreviations

AC:

adenocarcinoma C3HBA

EA:

Ehrlich ascites carcinoma

HE:

hepatoma BW7756

JS:

Jensen sarcoma

LL:

lymphatic leukemia BW5147

LS:

lymphosarcoma 6C3HED

ME:

melanoma B16

NH:

Novikoff hepatoma

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Authors and Affiliations

  1. Innere Klinik u. Poliklinik (Tumorforschung), Federal Republic of Germany

    Leopolde J. Anghileri

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  1. Leopolde J. Anghileri
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This work has been supported by the Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen.

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Anghileri, L.J. Calcium, magnesium and phosphorus in experimental tumors: effects of the age of the tumor. Z. Krebsforsch. 81, 109–118 (1974). https://doi.org/10.1007/BF00304151

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  • DOI: https://doi.org/10.1007/BF00304151

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