Summary
Swiss mice were treated i.p. with DMN and DEN either alone or simultaneously. In comparison to controls, the lung tumour incidence was increased in the carcinogen treated groups. Whereas DMN frequently caused lung carcinomata, DEN treated mice showed mainly lung adenomata; atypical adenomata were mostly found after simultaneous applications of DMN and DEN. Retroperitoneal vascular tumours and kidney adenomata were observed only after DMN treatment. Forestomach papillomata were seen in the groups receiving DEN and DMN + DEN. The rate of malignant lymphomata for all carcinogen treated mice fluctuated within the realm of a spontaneous tumour rate.
Zusammenfassung
Swiss-Mäuse erhielten intraperitoneal entweder DMN oder DEN oder beide Substanzen simultan, wodurch sich vergleichsweise zu den Kontrollen eine höhere Lungentumorrate ergab: Während DMN behandelte Tiere gehäuft Carcinome zeigten, wurden nach simultaner DMN + DEN-Behandlung vorwiegend atypische Adenome bzw. nach DEN-Gaben Adenome beobachtet. Die Behandlung nur mit DMN führte bei den Swiss-Mäusen noch zu retroperitonealen vasculären Neoplasmen und zu einigen Nierenadenomen. Papillome des Vormagens fanden sich bei Tieren der DEN bzw. DMN + DEN-Versuchsgruppen. Die Anzahl der nachgewiesenen Lymphome in allen carcinogen-behandelten Tieren bewegt sich im Bereich der Spontantumorrate
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References
Cardesa,A., Pour,P., Rustia,M., Althoff,J., Mohr,U.: The syncarcinogenic effect of methylcholanthrene and dimethylnitrosamine in Swiss mice. Z. Krebsforsch. 79, 98–107, (1973)
Cardesa,A., Pour,P., Althoff,J., Mohr,U.: Vascular tumours in female Swiss mice after intraperitoneal injection of dimethylnitrosamine. J. nat. Cancer Inst. 51, 201–208 (1973)
Clapp,N.K., Tyndall,R.L., Otten,J.A.: Differences in tumour types and organ susceptibility in Balb/c mice following dimethylnitrosamine and diethylnitrosamine. Cancer Res. 31, 196–198 (1971)
Hecker,E.: Aktuelle Probleme der Krebsentstehung. Z. Krebsforsch. 78, 99–122 (1972)
Hilfrich,J., Althoff,J., Mohr,U.: Untersuchungen zur Stimulation der Lungentumorrate durch Diäthylnitrosamin bei 0–20 Mäusen. Z. Krebsforsch. 75, 240–242 (1970)
Mirvish,S., Kaufman,L.: A study of nitrosamines and S-carboxyl derivatives of cysteine as lung carcinogens in adult SWR mice. Int. J. Cancer 6, 69–73 (1970)
Takayama,S., Oota,K.: Induction of malignant tumours in various strains of mice by oral administration of N-nitrosodimethylamine and N-nitrosodiethylamine. Gann 56, 189–199 (1965)
Terracini,B., Palestro,G., Ramella Gigliardi,M., Montesano,R.: Carcinogenicity of dimethylnitrosamine in Swiss mice. Brit. J. Cancer 20, 871–876 (1966)
Toth,B., Magee,P.N., Shubik,P.: Carcinogenesis study with dimethylnitrosamine administered orally to adult and subcutaneously to newborn Balb/c mice. Cancer Res. 24, 1712–1722 (1964)
Toth,B., Shubik,P.: Carcinogenesis in AKR mice injected at birth with benzo (a) pyrene and dimethylnitrosamine. Cancer Res. 27, 42–51 (1967)
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Supported by U.S. Public Health Serivce Contract No. 43-68-959 from the National Cancer Institute.
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Cardesa, A., Pour, P., Althoff, J. et al. Effects of intraperitoneal injections of dimethyl- and diethylnitrosamine, alone or simultaneously on Swiss mice. Z. Krebsforsch. 82, 233–238 (1974). https://doi.org/10.1007/BF00304061
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DOI: https://doi.org/10.1007/BF00304061