Skip to main content

Chromosome localization of the genes for ENO1, HK1, ADK, ACP2, MPI, ITPA, ACON1 and α-GAL in the American mink (Mustela vison)

Theoretical and Applied Genetics volume 67, pages 59–65 (1983)Cite this article

Summary

Twenty-eight American mink × Chinese hamster somatic cell hybrids were analysed for the expression of mink enzymes and the segregation of mink chromosomes. The results demonstrated that the gene for enolase-1 is located on the long arm of mink chromosome 2, and those for hexokinase-1 and adenosine kinase, on its short arm. Segregation analysis of mink chromosomes and mink acid phosphatase-2, mannose phosphate isomerase, inosine triphosphatase and aconitase-1 provided data allowing us to assign the genes for these markers to mink chromosomes 7, 10, 11 and 12, respectively. The expression of mink α-galactosidase was highly coincidental with mink × chromosome as well as with its markers: hypoxanthine-phosphoribosyltransferase, glucose-6-phosphate dehydrogenase and phosphoglycerate kinase-1. This result confirms the assignment of the gene for α-galactosidase to the mink × chromosome.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

References

  • Cowmeadow MP, Ruddle FH (1978) Computer-assisted statistical procedures for somatic cell gene assignment. Cytogen Cell Genet 22:694–697

    Google Scholar 

  • Créau-Goldberg N, Cochet C, Turleau C, de Grouchy J (1981) Comparative gene mapping of man and Cebus capucinus: a study of 23 enzymatic markers. Cytogen Cell Genet 31:228–239

    Google Scholar 

  • Garver JJ, Pearson PL, Estop A, Dijksman TM, Wijnen LMM, Vesterveld A, Meera Khan P (1977) Gene assignments to the presumptive homologs of human chromosomes 1, 6, 11, 12 and × in the Pongidae and Cercopithecoidae. Hum Gene Mapping 4:564–569

    Google Scholar 

  • Harris H, Hopkinson DA (1976) Handbook of enzyme electrophoresis in human genetics. North-Holland, Amsterdam

    Google Scholar 

  • Heuertz S, Hors-Cayla M-C (1981) Cattle gene mapping by somatic cell hybridization study of 17 enzyme markers. Cytogen Cell Genet 30:137–145

    Google Scholar 

  • Jones C, Kao F-T (1978) Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11. Hum Genet 45:1–10

    Google Scholar 

  • Lalley PL, Francke U, Minna JD (1978a) Homologous genes for enolase, phosphogluconate dehydrogenase, phosphoglucomutase, and adenylate kinase are syntenic on mouse chromosome 4 and human chromosome Ip. Proc Natl Acad Sci USA 75:2382–2386

    Google Scholar 

  • Lalley PA, Francke U, Minna JD (1978b) Assignment of the genes coding for pyrophosphatase and hexokinase-1 to mouse chromosome 10: implications for comparative gene mapping in man and mouse. Cytogen Cell Genet 22:570–572

    Google Scholar 

  • Lasserre C, Aviles-Aubert D, Gross M-S, van Cong N, Jami J (1981) Conservation of the syntenic group ENO-PGD-PGM in mammals: its assignment to chromosome 2 in the Chinese hamster. Ann Genet 24:133–136

    Google Scholar 

  • Leinwand L, Fournier REK, Nichols EA, Ruddle FH (1978) Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Cytogen Cell Genet 21:77–85

    Google Scholar 

  • McKusick VA (1980) The anatomy of the human genome. J Hered 71:370–391

    Google Scholar 

  • Nash WG, O'Brien SJ (1982) Conserved regions of homologous G-banded chromosomes between orders in mammalian evolution: carnivores and primates. Proc Natl Acad Sci USA 79:6631–6635

    Google Scholar 

  • O'Brien SJ, Nash WG (1980) Somatic cell analysis of enzyme structural genes of the domestic cat (Felis catus). Carnivore Genet Newslett 4:81–90

    Google Scholar 

  • Ohno O (1974) Conservation of ancient linkage groups in evolution and some insight into the genetic regulatory mechanism of inactivation. Cold Spring Harbor Symp Quant Biol 38:155–164

    Google Scholar 

  • Pearson PL, Roderick TH, Davisson M, Lalley PA, O'Brien SJ (1982) Report of the commitee on comparative mapping. Cytogen Cell Genet 32:208–220

    Google Scholar 

  • Rebourcet R, van Cong N, Frézal J, Finaz C, Cochet C, de Grouchy J (1975) Chromosome nl of man and chimpanzee: identity of gene mapping for the three loci PPH, PGM1, and Pep-C. Humangenetik 29:337–340

    Google Scholar 

  • Rubtsov NB, Radjabli SI, Gradov AA, Serov OL (1981a) Chinese hamster × American mink somatic cell hybrids: characterization of a clone panel and assignment of the mink genes for malate dehydrogenase, NADP-1 and malate dehydrogenase, NAD-1. Theor Appl Genet 60:99–106

    Google Scholar 

  • Rubtsov NB, Radjabli SI, Gradov AA, Serov OL (1981b) Chromosome localization of three syntenic gene pairs in the American mink (Mustela vison). Cytogen Cell Genet 31:184–187

    Google Scholar 

  • Rubtsov NB, Radjabli SI, Gradov AA, Serov OL (1982a) Chromosome localization of the genes for isocitrate dehydrogenase-1, isocitrate dehydrogenase-2, glutathione reductase, and phosphoglycerate kinase-1 in the American mink (Mustela vison). Cytogen Cell Genet 33:256–260

    Google Scholar 

  • Rubtsov NB, Gradov AA, Serov OL (1982b) Chromosome localization of the loci GOT1, PP, NP, SOD1, PEPA and PEPC in the American mink (Mustela vison). Theor Appl Genet 63:331–336

    Google Scholar 

  • Säidi-Mehtar N, Hors-Cayla M-C, van Cong N (1981) Sheep gene mapping by somatic cell hybridization: four syntenic groups ENO1-PGD, ME1-PGM3, LDHB-PEPB-TPI, and G6PD, PGK, GALA. Cytogen Cell Genet 30:193–204

    Google Scholar 

  • Shows TB, Ruddle FH (1968) Malate dehydrogenase: evidence for tetrameric structure in Mus musculus. Science 160:1356–1357

    Google Scholar 

  • Stallings RL, Siciliano MJ (1982) Assignment of ADA, ITA, AK1 and AK2 to Chinese hamster chromosomes. J Hered 73:399–404

    Google Scholar 

  • Swallow DM, Harris H (1972) A new variant of the placental acid phosphatase: its implications regarding their subunit structures and genetical determinants. Ann Hum Genet 36:141–152

    Google Scholar 

  • Van der Heiden BS (1969) Genetic studies of human erythrocyte inosine triphosphatase. Biochem Genet 3:289–294

    Google Scholar 

  • Wijnen LMM, Grzeschik K-H, Pearson PL, Meera Khan P (1977) The human PGM-2 and its chromosomal localization in man-mouse hybrids. Hum Genet 37:271–278

    Google Scholar 

  • Womack JE (1982) Biochemical loci of the mouse (Mus musculus). Isozyme Bull 15:56–64

    Google Scholar 

Download references

Author information

Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch of the Academy of Sciences of the USSR, 90, Novosibirsk, USSR

    A. A. Gradov, N. B. Rubtsov, A. G. Shilov, M. N. Bochkarev & O. L. Serov

Authors
  1. A. A. Gradov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. B. Rubtsov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. G. Shilov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. N. Bochkarev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. O. L. Serov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Communicated by Y. Gleba

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gradov, A.A., Rubtsov, N.B., Shilov, A.G. et al. Chromosome localization of the genes for ENO1, HK1, ADK, ACP2, MPI, ITPA, ACON1 and α-GAL in the American mink (Mustela vison). Theoret. Appl. Genetics 67, 59–65 (1983). https://doi.org/10.1007/BF00303923

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00303923

Key words

  • Gene maping
  • Somatic cell hybrids
  • Enolase-α-galactosidase
  • American mink
  • Chinese hamster