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A High-resolution map of 1.6 Mb in the Down syndrome region: a new map between D21S55 and ETS2

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References

  • Albertsen, H.M., Abderrahim, H., Cann, H.M., Dausset, J., Le Paslier, D., Cohen, D. (1990). Construction and characterization of a yeast artificial chromosome library containing seven haploid human genome equivalents. Proc. Natl. Acad. Sci. USA 87, 4256–4260

    Google Scholar 

  • Bosch, A., Nunes, V., Patterson, D., Estivill, X. (1993). Isolation and characterization of 14 CA-repeat microsatellites from human chromosome 21. Genomics, 18, 151–155

    Google Scholar 

  • Boulukos, K.E., Pognonec, P., Begue, A., Galibert, F., Gesquières, J.C., Stéhelin, D., Ghysdael, J. (1988). Identification in chickens of an evolutionarily conserved cellular ets-2 gene (c-ets-2) encoding molecular proteins related to the products of the c-ets protooncogene. EMBO J. 7, 697–705

    Google Scholar 

  • Burke, D.T., Carle, G.F., Olson, M.V. (1987) Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science, 236, 806–812

    Google Scholar 

  • Carritt, B., Litt, M. (1989) Report of the committee on the genetic constitution of chromosomes 20 and 21. Cytogenet. Cell Genet. 51, 358–371

    Google Scholar 

  • Chumakov, I., Rigault, P., Guillou, S., Ougen, P., Billaut, A., Guasconi, G., Gervy, P., Legall, I., Soularue, P., Grinas, L., Bougueleret, L., Bellané-Chantelot, C., Lacroix, B., Barillot, E., Gesnouin, P., Pook, S., Vaysseix, G., Frelat, G., Schmitz, A., Sambucy, J.L., Bosch, A., Estivill, X., Weissenbach, J., Vignal, A., Riethman, H., Cox, D., Patterson, D., Gardiner, K., Hattori, M., Sakaki, Y., Ichikawa, H., Ohki, M., Le Paslier, D., Heilig, R., Antonarakis, S., Cohen, D. (1992). Continuum of overlapping clones spanning the entire human chromosome 21q. Nature 359, 380–387

    Google Scholar 

  • Crété, N., Delabar, J.M., Sinet, P.M., Créau-Goldberg, N. (1991) Accurate evaluation of the sizes of DNA fragments (from 30 to 4700 kb) in pulsed field gel electrophoresis. Bio Techniques 11, 711–717

    Google Scholar 

  • Crété, N., Delabar, J.M., Rahmani, Z., Yaspo, M.L., Kraus, J., Marks, A., Sinet, P.M., Créau-Goldberg, N. (1993a) Partial physical map of human chromosome 21 from fibroblast and lymphocyte DNA. Hum. Genet 91, 245–253

    Google Scholar 

  • Crété, N., Gosset, Ph., Théophile, D., Duterque-Coquillaud, M., Blouin, J.L., Vayssettes, C., Sinet, P.M., Créau-Goldberg, N. (1993b) Mapping the Down syndrome chromosome region. Establishment of a YAC contig spanning 1.2 megabases. Eur. J. Hum. Genet. 1, 51–63

    Google Scholar 

  • Delabar, J.M., Théophile, D., Rahmani, Z., Chettouh, Z., Blouin, J.L., Prieur, M., Noël, B., Sinet, P.M. (1993a) Molecular mapping of twenty-four features of Down syndrome on chromosome 21. Eur. J. Hum. Genet. 1, 114–124

    Google Scholar 

  • Delabar, J.M., Créau, N., Sinet, P.M., Ritter, O., Antonarakis, S.E., Burmeister, M., Chakravarti, A., Nizetic, D., Ohki, M., Patterson, D., Petersen, M.B., Reeves, R.H., Van Broeckhoven (1993b) Report of the Fourth International Workshop on Human Chromosome 21. Genomics, 18, 735–745

    Google Scholar 

  • Dufresne-Zacharia, M.C., Dahmane, N., Théophile, D., Orti, R., Chettouh, Z., sinet, P.M., Delabar, J.M. (1994) 3.6 Mb genomic and YAC physical map of the Down syndrome Chromosome Region on chromosome 21. Genomics, 19, 462–469

    Google Scholar 

  • Feinberg, A.P., Vogelstein, B. (1984) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132, 6–13

    Google Scholar 

  • Gyapay, G., Morissette, J., Vignal, A., Dib, C., Fizames, C., Millasseau, P., Marc, S., Bernardi, G., Lathrop M., Weissenbach J. (1994) The 1993–94 Généthon human genetic linkage map. Nature Genetics 7, 246–339

    Google Scholar 

  • Larin, Z., Monaco, A.P., Lehrach, H. (1992) Yeast artificial chromosomes libraries containing large inserts from mouse and human DNA. Proc. Natl. Acad. Sci. USA 88, 4123–4128

    Google Scholar 

  • Lindsay, S., Bird, A.P. (1987) Use of restriction enzymes to detect potential gene sequences in mammalian DNA. Nature 327, 336–338

    Google Scholar 

  • Rahmani, Z., Blouin, J.L., Créau-Goldberg, N., Watkins, P.C., Mattei, J.F., Poissonnier, M., Prieur, M., Chettouh, Z., Nicole, A., Aurias, A., Sinet, P.M., Delabar, J.M. (1989) Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome. Proc. Natl. Acad. Sci. USA 86, 5958–5962

    Google Scholar 

  • Ross, M.K., Nizetic, D., Nguyen, C., Knights, C., Vatecheva, R., Burden, N., Douglas, C., Zehetner, G., Ward, D.C., Baldini, A., Lehrach, H. (1992) Selection of a human chromosome 21 enriched YAC sub-library using a chromosome-specific composite probe. Nature Genet. 1, 284–290

    Google Scholar 

  • Stuyver, L., Van Camp, G., Van de Voorde, A., Van Broeckhoven, C., Van Heuverswyn, H. (1991) Isolation of chromosome 21 encoded expressed sequences. Cytogenet. Cell Genet. 58, 2039–2040.

    Google Scholar 

  • Tanzi, R.E., Romano, D.M., Berger, R., Buraczynska, M.J., Gaston, S.M., Kurnit, D.M., Patterson, D., Gusella, J.F., Stewart, G.D. (1992) Sequence-tagged sites (STSs) for a set of mapped markers on chromosome 21. Genomics, 14, 498–502

    Google Scholar 

  • Tassone, F., Cheng, S., Gardiner, K. (1992) Analysis of chromosome 21 yeast artificial chromosome (YAC) clones. Am. J. Hum. Genet. 51, 1251–1264.

    Google Scholar 

  • Van Keuren, Drabkin H., Watkins, P., Gusella, J., Patterson, D. (1985) Regional mapping of DNA sequences to chromosome 21. Cytogenet. Cell Genet. 40, 768–769.

    Google Scholar 

  • Watkins, P.C., Watkins, P.A., Hoffman, N., Stanislovitis, P. (1985) Isolation of single-copy probes detecting DNA polymorphism from a cosmid library of chromosome 21. Cytogenet. Cell Genet. 40, 773–774

    Google Scholar 

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Gosset, P., Crété, N., Ait Ghezala, G. et al. A High-resolution map of 1.6 Mb in the Down syndrome region: a new map between D21S55 and ETS2 . Mammalian Genome 6, 127–130 (1995). https://doi.org/10.1007/BF00303257

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  • DOI: https://doi.org/10.1007/BF00303257

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