Zusammenfassung
An Proben von 24 Std-Urin, gesammelt von 36 Otosklerosekranken und von 38 männlichen Patienten ohne Otosklerose wurde der Gehalt von Hexuronsäure (als Index des Gesamtgehaltes an sauren Mucopolysacchariden) bestimmt. Durch Elektrophorese wurden die einzelnen sauren Mucopolysaccharide analysiert. Bei den Patienten mit and ohne Otosklerose gab es keinen Unterschied in der Ausscheidung der Gesamtmucopolysaccharide oder der einzelnen Fraktionen.
Daraus wird gefolgert, daß die histochemischen Veränderungen der Grundsubstanz, denen eine Bedeutung für die Pathogenese der Otosklerose zugeschrieben wurde, sich nicht in der Urinausscheidung von sauren Mucopolysacchariden wider spiegeln. Dies würde dafür sprechen, daß solche Veranderungen sich auf die Otoskleroseherde beschränken and daß sic nicht Teile einer allgemeinen Mesenchymerkrankung darstellen, womit man die Otosklerose früher in Verbindung bringen zu müssen glaubte.
Summary
Twenty-four hour urine samples, collected from thirty-six otosclerotic and thirty-eight non-otosclerotic male patients, were assayed for hexuronic acid (an index of total acid mucopolysaccharide content). The urines were electrophoresed in order to identify the individual acid mucopolysaccharides. No differences in total acid mucopolysaccharide excretion were observed to occur between otosclerotic and non-otosclerotic patients. The individual mucopolysaccharides comprising the total fraction were identical in the two groups; and no abnormal components were found in any of the samples, otosclerotic or non-otosclerotic. Thus, it may be concluded that changes in the ground substance, demonstrated histochemically and postulated to occur in the pathogenesis of otosclerosis, are not reflected in the urinary excretion of acid mucopolysaccharides. This would indicate that these changes are confined to the otosclerotic focal areas and are not part of the generalized mesenchymopathy with which otosclerosis is believed to be associated.
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Soifer, N., Waltner, J.G., Endahl, G.L. et al. Biochemical studies of otosclerosis: Urinary acid mucopolysaccharides. Arch. Klin. Exp. Ohr.-, Nas.- U. Kehlk. Heilk. 197, 1–6 (1970). https://doi.org/10.1007/BF00300281
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DOI: https://doi.org/10.1007/BF00300281