Abstract
Intestinal muscle and the autonomic nervous system constitute a neuromuscular unit. A clinical study was undertaken to seek neurogenic causes of impaired motility affecting the rectosigmoid junction and rectum. Patients with primary chronic constipation were shown by enzyme-histochemical examination of biopsies to have neuronal colonic dysplasia of the rectosigmoid, whereas the latter was normally innervated in healthy controls. The present investigations provide a fresh insight, underpinned by histological findings, into the aetiology of chronic constipation and make a contribution to its operative treatment.
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Stoss, F. Neuronal dysplasia. Int J Colorect Dis 5, 106–112 (1990). https://doi.org/10.1007/BF00298481
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DOI: https://doi.org/10.1007/BF00298481