Summary
The blood glucose and plasma insulin responses to some simple carbohydrates (glucose, fructose, lactose) and some complex ones (apples, potatoes, bread, rice, carrots and honey) were studied in 32 Type 2 (non-insulin-dependent) diabetic patients. Blood glucose and plasma insulin were measured at zero time and then at 15, 30, 60, 90 and 120 min after ingestion of 25 g glucose, fructose or lactose, or 30 g honey, 50 g white bread, 125 g white rice or potatoes, 150 g apples or 260 g carrots. Maximum blood glucose and plasma insulin responses were recorded 60 min after ingestion of each test meal. At this time the increases in blood glucose and in plasma insulin were significantly higher after the more refined carbohydrates (glucose, fructose and lactose) than after the more complex ones (apples, potatoes, rice, carrots and honey,-p < 0.01). Counting the blood glucose increase after glucose as 100%, the corresponding increases in glycaemia for other carbohydrates were: fructose, 81.3%; lactose, 68.6%; apples, 46.9%; potatoes, 41.4%; bread, 36.3%; rice, 33.8%; honey, 32.4% and carrots, 16.1%.
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Anderson JW (1977) Effect of carbohydrate restriction and high carbohydrate diets on men with chemical diabetes. Am J Clin Nutr 30: 402–408
Anderson JW, Karonnos D (1978) Beneficial effects of high carbohydrate, high fiber diets for insulin-treated diabetic men. Diabetes 27 (Suppl 2): 443 (Abstract)
Aro A, Uusitupa M, Vontilainen E, Hersio K, Korhonen T, Siitonen O (1981) Improved diabetic control and hypocholesterolemic effect induced by long-term dietary supplementation with guar gum in Type 2 (insulin-independent) diabetes. Diabetologia 21: 29–33
Bohannon NV, Karam JH, Forahem PH (1978) Advantages of fructose ingestion over sucrose and glucose in humans. Diabetes 27 (Suppl 2): 483–487
Bosello O, Ostuzzi R, Armellini F, Micciolo RM, Ludovico AS (1980) Glucose tolerance and blood lipids in bran fed patients with impaired glucose tolerance. Diabetes Care 3: 46–49
Brunzell JD, Lerner RL, Porte D, Bierman EL (1971) Improved glucose tolerance with high carbohydrate feeding in mild diabetes. N Engl J Med 284: 521–524
Cohen M, Martin FR (1979) Guar crispbread in the diabetic diet. Br Med J 2: 616–617
Collings P, Williams C, MacDonald I (1981) Effect of cooking on serum glucose and insulin responses to starch. Br Med J 282: 1032–1036
Crapo PA, Reaven G, Olefsky J (1976) Plasma glucose and insulin responses to orally administered simple and complex carbohydrates. Diabetes 25: 741–747
Crapo PA, Kolterman OG, Waldek N, Reaven GM, Olefsky JM (1980) Postprandial hormonal responses to different types of complex carbohydrates in individuals with impaired glucose tolerance. Am J Clin Nutr 33: 1723–1728
Cristacopoulos PD, Karamanos BG, Zachariou NZ, Tountas CD, Komninos ZD (1980) Different insulin and blood glucose levels after administration of equal amounts of carbohydrates contained in different foodstuffs. Diabetologia 19: 264 (Abstract)
Dewar J, Garcia WP, Shenfield GM (1979) Guar and diabetes. Lancet 1: 612 (Letter)
Douglas JM (1975) Raw diet and insulin requirements. Ann Intern Med 82: 61–65
Goulder TJ, Alberti KGMM (1978) Dietary fibre and diabetes. Diabetologia 15: 285–287
Goulder TJ (1979) Guar and diabetes. Lancet 1: 612 (Letter)
Haber GB, Heaton KW, Murphy D, Burroughs LF (1977) Depletion and disruption of dietary fibre. Effects on satiety, plasmaglucose, and serum insulin. Lancet 2: 679–682
High-fibre diets and diabetes (Editorial) (1981) Lancet 1: 423
Holt S, Carter D, Heeding R, Prescott L, Tothill P (1979) Effect of gel fibre on gastric emptying and absorption of glucose and paracetamol. Lancet 1: 636–639
Ionescu-Tîrgovişte C, Sîntu E, Mihalache N, Cheţa D, Boboia D, Constantinescu A, Fachler E, Sgarbură M (1979) The hyperglycaemic effect of some concentrated carbohydrates in non-insulin dependent diabetics. Acta Diabetol Romana 5: 54–61
Jarret RJ (1981) How much carbohydrate? Diabetologia 20: 507 (Letter)
Jarrett RJ (1981) More about carbohydrates. Diabetologia 21: 427–428 (Letter)
Jenkins DJA, Leeds AR, Gassull MA, Cochet BJ, Alberti KGMM (1977) Decrease in postprandial insulin and glucose concentrations by guar and pectin. Ann Intern Med 86: 20–25
Jenkins DJA, Wolever TMS, Ninehan R, Taylao R, Metz LG, Bacon S, Hockaday TDR (1978) Guar crispbread in the diabetic diet. Br Med J 2: 1744–1746
Jenkins DAJ, Wolever TMS, Leeds AR, Gassull MA, Dilawari JB, Goff DV, Metz GL, Alberti GKMM (1978) Dietary fibres, fibre analogues and glucose tolerance: importance of viscosity. Br Med J 1: 1392–1394
Jenkins DJA, Nineham R, Craddock C, Craig-McFeely P, Donaldson K, Leigh T, Snook J (1979) Fibre and diabetes. Lancet 1: 434–435
Jenkins DJA, Wolever TSM, Taylor RH, Ghafary H, Jenkins AL, Barker H, Jenkins MJA (1980) Rate of digestion of foods and postprandial glycaemia in normal and diabetic subjects. Br Med J 2: 14–17
Jenkins DJA, Wolever TMS, Taylor RH, Barker HN, Fielden H, Baldwin JM, Bowling AC, Newman HC, Jenkins AL, Goff DV (1981) Glycemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34: 362–366
Karlander SG, Andersen E, Kindstedt K, Helleström K (1980) Effects of two sources of starch on glucose and insulin levels in Type 2 diabetic patients. Diabetologia 19: 287 (Abstract)
Kay RM, Grobin W, Trach NS (1981) Diets rich in natural fibre improve carbohydrate tolerance in maturity-onset, non-insulin dependent diabetics. Diabetologia 20: 18–21
Kiehm TG, Anderson JW, Ward K (1976) Beneficial effect of a high carbohydrate diet on hyperglycemic diabetic men. Am J Clin Nutr 29: 895–899
MacDonald I, Keyser A, Pacy D (1978) Some effects, in men, of varying the load of glucose, sucrose, fructose, or sorbitol on various metabolites in blood. Am J Clin Nutr 31: 1305–1311
Mann JI, Simpson HCR (1980) Dietary management of maturity-onset diabetes. Br Med J 2: 62 (Letter)
Mann JI, Kinmonth AL, Todd E, Angus RM, Simpson HCR, Hockaday TDR (1981) High fibre diets and diabetes. Lancet 1: 731 (Letter)
Miranda PJ, Horwitz DL (1978) High-fibre diets in the treatment of diabetes mellitus. Ann Intern Med 88: 482–486
Miller M, Dreker WR, Owens JE, Craig JW, Woodward H (1962) Metabolism of intravenous fructose and glucose in normal and diabetic subjects. J Clin Invest 31: 115–125
O'Dea K, Nestel PJ, Antonoff L (1980) Physical factors influencing postprandial glucose and insulin response to starch. Am J Clin Nutr 33: 760–765
Reaven GM (1980) How much carbohydrate? Diabetologia 19: 409–413
Rivelese A, Riccardo G, Giacco A, Pacioni D, Genovese S, Mattioli PL, Mancini M (1980) Effect of dietary fibre on glucose control and serum lipoproteins in diabetic patients. Lancet 2: 447–450
Schauberger G, Brinck UC, Suldner G, Spaethe R, Niklas L, Otto H (1978) Exchange of carbohydrates according to their effect on blood glucose. Diabetes 26: 415–417
Schusdziarra V, Dangel G, Kelir M, Henrrich J, Pfeiffer EF (1981) Effect of solid and liquid carbohydrates upon postprandial pancreatic endocrine function. J Clin Endocrinol Metab 53: 16–20
Simpson RW, Mann JI, Eaton J (1979) High-carbohydrate diets and insulin dependent diabetics. Br Med J 2: 523–525
Simpson RW, Mann JI, Eaton J, Moore RA, Carter R, Hockaday TDR (1979) Improved glucose control in maturity onset diabetes treated with high carbohydrate-modified fat diet. Br Med J 1: 1753–1756
Simpson HCR, Simpson RW, Lousley S, Carter RD, Geekie M, Hochaday TDR, Mann JI (1981) A high carbohydrate leguminous fibre diet improves all aspects of diabetic control. Lancet 1: 1–5
Spaethe R, Brinck UC, Sabin J, Wubbens D, Otto H (1972) Echanges des hydrates de carbone d'après le principe des équivalences biologiques dans le régime pour diabétiques. In: Journées Annuelles de Diabétologie Hôtel-Dieu. Ed. Flammarion, Paris, pp 253–259
Uzzan M (1971) Note sur la répartition des diverses glucydes dans la ration alimentaire des diabétiques. Cahiers Nutr Diét 6: 61–63
Vaaler S, Hanssen KF, Aagenaes Ø (1979) Influence of different kinds of dietary fibre on blood glucose responses after a carbohydrate-rich meal in juvenile diabetics. Excerpta Med Int Congress Series 481–241 (Abstract)
Weinsier RL, Seeman A, Herrera MG, Assal JP, Soeldner JS, Gleasson RE (1974) High and low carbohydrate diets in diabetes mellitus. Study of effects on diabetic control, insulin secretion and blood lipids. Ann Intern Med 80: 332–341
Williams DRP, James WPT (1979) Guar and diabetes. Lancet 1: 612–613
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Ionescu-Tîrgovişte, C., Popa, E., Sîntu, E. et al. Blood glucose and plasma insulin responses to various carbohydrates in Type 2 (non-insulin-dependent) diabetes. Diabetologia 24, 80–84 (1983). https://doi.org/10.1007/BF00297385
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DOI: https://doi.org/10.1007/BF00297385