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Elevated serum uric acid — a facet of hyperinsulinaemia

Summary

In a representative sample of the adult Jewish population in Israel (n=1016) excluding known diabetic patients and individuals on antihypertensive medications, serum uric acid showed a positive association with plasma insulin response (sum of 1- and 2-hour post glucose load levels) in both males (r=0.316, p<0.001) and females (r=0.236, p<0.001). This association remained statistically significant in both sexes (p<0.001) after accounting by multiple regression analysis for age and major correlates of serum uric acid, i.e. body mass index, glucose response (sum of 1- and 2-hour post load levels), systolic blood pressure and total plasma triglycerides. The net portion of the variance of serum uric acid attributable to insulin response was 12% in males and 8% in females, the total variance accountable by all these variables being 17% and 19% respectively. We conclude that elevated serum uric acid is a feature of hyperinsulinaemia/insulin resistance.

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Modan, M., Halkin, H., Karasik, A. et al. Elevated serum uric acid — a facet of hyperinsulinaemia. Diabetologia 30, 713–718 (1987). https://doi.org/10.1007/BF00296994

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Key words

  • Serum uric acid
  • hyperinsulinaemia
  • Type 2 (non-insulin-dependent) diabetes
  • impaired glucose tolerance
  • hypertension
  • obesity
  • plasma triglycerides