Abstract
A model of renal infection due to lower urinary tract obstruction and biofilm disease was constructed for the study of renal scarring by inserting glass beads coated with bacterial biofilm into the bladder of rats and then clamping the urethra. We previously reported the effect of antimicrobial therapy used in combination with the anti-inflammatory agent prednisolone to prevent renal scarring. In this study we investigated the effect of prednisolone on renal scar formation using our new model. Renal scarring could not be prevented in the group in which prednisolone was administered in the period during which the urethra was regularly being clamped. In contrast, scarring was prevented in the group that began to receive prednisolone after the period of clamping had ended. Therefore, in cases of lower urinary tract obstruction prednisolone should only be administered for the prevention of renal scarrring after the obstruction has been resolved.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bille G, Glauser MP (1982) Protection against chronic pyelonephritis in rats by suppression of acute suppuration: Effect of colchicine and neutropenia. J Infect Dis 146:220
Glauser MP, Lyons JM, Braude AI (1978) Prevention of chronic experimental pyelonephritis by suppression of acute suppuration. J Clin Invest 61:403
Hagberg L, Engberg I, Freter R, Lam J, Ollings S, Svanborg Eden C (1983) Ascending, unobstructed urinary tract infection in mice caused by pyelonephritogenic Escherichia coli of human origin. Infect Immun 40:273
Haraoka M, Matsumoto T, Mizunoe Y, Ogata N, Takahashi K, Kubo S, Tanaka M, Kumazawa J (1993) Effect of prednisolone on renal scarring in rats following infection with Serratia marcescens. Ren Fail 15:567
Haraoka M, Matsumoto T, Takahashi K, Kubo S, Tanaka M, Kumazawa J (1994) Suppression of renal scarring by prednisolone combined with ciprofloxacin in ascending pyelonephritis in rats. J Urol 151:1078
Matsumoto T, Mizunoe Y, Sakamoto N, Kumazawa J (1990) Suitability of colchicine and superoxide dismutase for the suppression of renal scarring following an infection with bacteria showing mannose-sensitive pili. Nephron 56:130
Matsumoto T, Mizunoe Y, Ogata N, Tanaka M, Kumazawa J (1991) Role of superoxide in renal scarring following infection by MS-piliated bacteria. Urol Res 19:229
Matsumoto T, Mizunoe Y, Ogata N, Tanaka M, Takahashi K, Kumazawa J (1992) Antioxidant effect on renal scarring following infection of mannose-sensitive-piliated bacteria. Nephron 60:210
Mclorie GA, McKenna PH, Jumper BM, Churchill BM, Gilmore F, Khoury AE (1990) High grade vesicoureteral reflux: analysis of observational therapy. J Urol (2) 144:537
Ransley PG, Risdon RA (1979) The renal papilla intrarenal reflux, and chronic pyelonephritis. In: Hodson J, Kincaid-Smith PS (eds) Reflux neuropathy. New York, p 126
Risdon RA (1981) Reflux nephropathy. Diagn Histopathol 4:61
Roberts JA, Kaack MB, Baskin G (1990) Treatment of experimental pyelonephritis in the monkey. J Urol 143:150
Skook SJ, Belman AB, Majd M (1987) A nonsurgical approach to the management of primary vesicoureteral reflux. J Urol (2) 138:941
Slotki IN, Asscher AW (1982) Prevention of scarring in experimental pyelonephritis in the rat by early antibiotic therapy. Nephron 30:262
Smellie J, Edwards D, Hunter N, Normand ICS. Prescod N (1975) Vesicoureteric reflux and renal scarring. Kidney Int [suppl 4] (8):65
Svenson SB (1982) Rapid identification of P-fimbriated Escherichia coli by a receptor-specific particle agglutination test. Infection 10:209
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Haraoka, M., Matsumoto, T., Takahashi, K. et al. Effect of prednisolone on ascending renal infection due to biofilm disease and lower urinary tract obstruction in rats. Urol. Res. 22, 383–387 (1995). https://doi.org/10.1007/BF00296880
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00296880