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Mapping of the interleukin 5 receptor gene to human Chromosome 3 p25–p26 and to mouse Chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences

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Abstract

Simple-sequence tandem repeat sequences in the 3′ UTR of interleukin 5 (IL5)-receptor gene of human and mouse are polymorphic in their length among humans and different strains of mice. In 20 different human Epstein-Barr virus (EBV)-transformed cell lines, six alleles of IL5R could be distinguished. In the mouse, three different alleles are found. With the human-specific IL5R tandem repeat marker in human-rodent somatic cell hybrids, the IL5R gene was mapped to human Chromosome (Chr) 3 p25–p26. With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus.

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Authors and Affiliations

  1. Syntex Research R7-201, 3401 Hillview Avenue, 94304, Palo Alto, California, USA

    Chaim O. Jacob & Kirk Mykytyn

  2. The Cancer Biology Program, Stanford University School of Medicine, 494305, Stanford, California, USA

    Chaim O. Jacob

  3. Division of Medical Oncology, University of Colorado Health Sciences Center, 80262, Denver, Colorado, USA

    Terry Varcony & Harry A. Drabkin

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  1. Chaim O. Jacob
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  2. Kirk Mykytyn
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  3. Terry Varcony
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  4. Harry A. Drabkin
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Jacob, C.O., Mykytyn, K., Varcony, T. et al. Mapping of the interleukin 5 receptor gene to human Chromosome 3 p25–p26 and to mouse Chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences. Mammalian Genome 4, 435–439 (1993). https://doi.org/10.1007/BF00296817

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  • DOI: https://doi.org/10.1007/BF00296817

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