Skip to main content
Log in

Analysis of the detrusor smooth muscle action potential

  • Original Articles
  • Published:
Urological Research Aims and scope Submit manuscript

Summary

A method is described to record bladder smooth muscle action potential (AP) data and subsequently in digitized form analyze the constitutive elements of the AP. Manipulation of digitized data can give accurate descriptive information on the AP configuration and kinetics. In the future this type of analysis will hopefully lead to more precise, quantitative information on changes in the smooth muscle AP kinetics with disease states and facilitate a clearer understanding of the pathophysiological processes underlying changes in detrusor contractility.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Arner A, Malmqvist U, Uvelius B (1985) Effects of Ca2+ on force-velocity characteristics of normal and hypertrophic smooth muscle of the rat portal vein. Acta Physiol Scand 124:525

    Google Scholar 

  2. Arner A, Malmqvist U, Uvelis B (1990) Metabolism and force in hypertrophic smooth muscle from rat urinary bladder. Am J Physiol 258:C923

    Google Scholar 

  3. Aronson RS (1980) Characteristics of action potentials of hypertrophied myocardium from rats with renal hypertension. Circ Res 47:443

    Google Scholar 

  4. Cameron JS, Myerburg RJ, Wong SS, Gaide MS, Gaide MS, Epstein K, Alvarez RT, Gelband H, Guse PA, Bassett AL (1983) Electrophysiologic consequences of chronic experimentally-induced left ventricular pressure overload. Am J Cardiol 2:481

    Google Scholar 

  5. Coltart DJ, Meldrum SJ (1970) Hypertrophic cardiomyopathy: an electrophysiological study. BMJ 4:217

    Google Scholar 

  6. Gelband H, Bassett AL (1973) Depressed transmembrane potentials during experimentally induced ventricular failure in cats. Circ Res 32:625

    Google Scholar 

  7. Mattiasson A, Uvelius B (1982) Canges in contractile properties in hypertrophic rat urinary bladder. J Urol 128:1340

    Google Scholar 

  8. Mostwin JL (1986) The action potential of guinea pig bladder smooth muscle J Urol 135:1299

    Google Scholar 

  9. Ten Eick RE, Gelband H, Kahn J, Bassett AL (1977) Changes in outward transmembrane currents of papillary muscle of cats with right ventricular hypertrophy (abstract). Circulation 56:47

    Google Scholar 

  10. Tholon C, Kreher P (1989) Altered electrical response to caffeine exposure in hypertrophied rat myocardium. Can J Physiol Pharmacol 67:1471

    Google Scholar 

  11. Tomita T (1966) Electrical response of smooth muscle to external stimulation in hypertonic solution. J Physiol (Lond) 183:450

    Google Scholar 

  12. Tritthart H, Leudcke H, Bayer R, Stierle H, Kaufmann R (1975) Right ventricular hypertrophy in the cat: an electrophysiological and anatomical study. J Mol Cell Cardiol 7:163

    Google Scholar 

  13. Van Koeveringe G, Mostwin JL, Mastrigt R van, Van Koeveringe BJ (1990) Effect of partial obstruction on force development in guinea pig bladder muscle (abstract). J Urol 143:335A

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Karim, O.M.A., Seki, N. & Mostwin, J.L. Analysis of the detrusor smooth muscle action potential. Urol. Res. 20, 173–176 (1992). https://doi.org/10.1007/BF00296533

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00296533

Key words

Navigation