Summary
Sections of formalin-fixed, paraffin-blocked tissue from 116 primary transitional cell carcinomas were stained immunohistochemically using a polyclonal antibody against the c-erbB-2 oncoprotein. Positive staining of cell membranes, known to correlate with gene amplification, was seen in 22 (19%) of the 116, with variable staining from tumour to tumour and within tumours themselves. Consistent with its mooted value as a prognosticator in bladder cancer, the c-erbB-2 oncoprotein was detected in 13 (of 40) grade III and 9 of the 26 muscle-invasive tumours examined compared to 1 (of 25) grade I and 6 (of 66) mucosa only (pTa) lesions. These results support further examination of c-erbB-2 expression in bladder cancer.
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Gardiner, R.A., Samaratunga, M.L.T.H., Walsh, M.D. et al. An immunohistological demonstration of c-erbB-2 oncoprotein expression in primary urothelial bladder cancer. Urol. Res. 20, 117–120 (1992). https://doi.org/10.1007/BF00296522
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DOI: https://doi.org/10.1007/BF00296522