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Renin-producing renal cell carcinomas—clinical and experimental investigations on a special form of renal hypertension

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Summary

The pathogenetic relationship between tumour and hypertension was investigated in 129 patients with renal cell carcinoma, of whom 41 (31.8%) were hypertensive. Of these 41 patients with renal tumours and hypertension, 6 (14.6%) were found to have primary reninism. In these patients the plasma renin activity in blood from the renal veins showed a tumour kidney to contralateral kidney ratio of between 4 and 7, and 2 patients also had secondary hyperaldosteronism. In the same 6 cases the renin content in the renal tumour tissue was significantly higher than that in tissue from the adjacent tumour-free renal cortex of the ipsilateral kidney. Immunohistochemical demonstration of renin in the tumour was only possible in these 6 cases. In 5 of these patients blood pressure returned to normal following nephrectomy; in the 6th case there was a drop in blood pressure after nephrectomy. In 3 renin-positive tumours examined, autonomous renin production was demonstrated in cell culture. Renin-producing renal cell carcinomas are an uncommon cause of renal hypertension. The differential diagnosis of hypertension should therefore also include renal tumour.

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Authors and Affiliations

  1. Department of Urology, University of Saarland, Homburg/Saar, FRG

    J. Steffens, H. U. Braedel, E. Isenberg & M. Ziegler

  2. Institute of Anatomy, University of Saarland, Homburg/Saar, FRG

    R. Bock

  3. Institute of Physiology, University of Heidelberg, Heidelberg, FRG

    C. P. Bührle

Authors
  1. J. Steffens
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  2. R. Bock
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  3. H. U. Braedel
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  4. E. Isenberg
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  5. C. P. Bührle
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  6. M. Ziegler
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Steffens, J., Bock, R., Braedel, H.U. et al. Renin-producing renal cell carcinomas—clinical and experimental investigations on a special form of renal hypertension. Urol. Res. 20, 111–115 (1992). https://doi.org/10.1007/BF00296521

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  • DOI: https://doi.org/10.1007/BF00296521

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