Skip to main content
SpringerLink
Log in

Localization exclusion of the HL-A genes from the short arm of human chromosome 5

  • Short Communications
  • Published:
Humangenetik Aims and scope Submit manuscript

Summary

A cri du chat patient with deletion of more than 3/4 of the short arm of one chromosome 5 was found to be heterozygous at both of the closely linked HL-A gene loci, thus demonstrating that the HL-A genes cannot be located on the missing segment.

Zusammenfassung

Bei einem Patienten mit Cri du chat-Syndrom und einer Chromosomendefizienz, die mehr als 3/4 des kurzen Armes eines Chromosoms 5 umfaßt, wurde Heterozygotie an beiden der enggekoppelten HL-A-Gene festgestellt. Damit können die HL-A-Gene nicht auf dem deletierten Abschmitt lokalisiert sein.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Bender, K., Burckhardt, K.: On the localization of genes on certain autosomes of man through chromosome aberrations. III. Exclusion of the possibility of gene assignment. Humangenetik 9, 75–85 (1970).

    PubMed  Google Scholar 

  • Brock, D. J. H., Singer, J. D.: Red cell triosephosphate isomerase and chromosome 5. Lancet 1970 II, 45–46.

    Google Scholar 

  • Kissmeyer-Nielsen, F., Thorsby, E.: Human transplantation antigens. Appendix: Current methods in histocompatibility testing. Transplant. Rev. 4, 1–176 (1970).

    Google Scholar 

  • Lejeune, J., Lafourcade, J., Berger, R., Vialette, J., Boeswillwald, M., Seringe, P., Turpin, R.: Trois cas de deletion partielle du bras court d'un chromosome 5. C. R. Acad. Sci. (Paris) 257, 3098–3102 (1963).

    Google Scholar 

  • Passarge, E.: Population cytogenetics, assignment of gene loci to autosomes, karyotype-phenotype correlations. A progress report on human cytogenetics. Humangenetik 9, 1–15 (1970).

    PubMed  Google Scholar 

  • Polani, P. E.: Autosomal imbalance and its syndromes, excluding Down's. Brit. med. Bull. 25, 81–93 (1969).

    PubMed  Google Scholar 

  • Sparkes, R. S., Carrel, R. E., Paglia, D. E.: Probable localization of a triosephosphate isomerase gene to the short arm of the number 5 human chromosome. Nature (Lond.) 224, 367–368 (1969).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Humangenetik der Universität Freiburg i. Br., Freiburg i. Br., Germany

    K. Bender

  2. Kinderklinik der Universität Freiburg i. Br., Freiburg i. Br., Germany

    F. Schindera

  3. Blood Bank and Blood Grouping Laboratory, The University Hospital, Århus, Denmark

    F. Kissmeyer-Nielsen

  4. Institut für Humangenetik und Anthropologie der Universität, Albertstraße 11, D-7800, Freiburg i. Br.

    K. Bender

Authors
  1. K. Bender
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Schindera
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Kissmeyer-Nielsen
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Supported by the Deutsche Forschungsgemeinschaft.

Supported by The Danish State Research Foundation and Einar Willumsen's Foundation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bender, K., Schindera, F. & Kissmeyer-Nielsen, F. Localization exclusion of the HL-A genes from the short arm of human chromosome 5. Hum Genet 11, 78–80 (1970). https://doi.org/10.1007/BF00296309

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00296309

Keywords

Search

Navigation