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Absence of interaction between furosemide and mitomycin C

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  • Furosemide, Mitomycin C
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Summary

The possible interaction between furosemide and mitomycin C (MMC) was studied in five patients. The pharmacokinetics of MMC were studied using an HPLC assay. Furosemide was administered prior to, or 120 min after MMC. Furosemide did not change the pharmacokinetics of MMC, nor did it change the amount of MMC excreted in the urine. There appears to be no interaction between the two drugs.

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Authors and Affiliations

  1. Department of Medical Oncology, Free University Hospital, Amsterdam

    J. Verweij, S. Kerpel-Fronius, M. Stuurman & H. M. Pinedo

  2. Department of Molecular Toxicology, Free University, Amsterdam

    J. de Vries

  3. Department of Medical Oncology, Rotterdam Cancer Institute, Rotterdam, The Netherlands

    J. Verweij

Authors
  1. J. Verweij
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  2. S. Kerpel-Fronius
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  3. M. Stuurman
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  4. J. de Vries
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  5. H. M. Pinedo
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Verweij, J., Kerpel-Fronius, S., Stuurman, M. et al. Absence of interaction between furosemide and mitomycin C. Cancer Chemother. Pharmacol. 19, 84–86 (1987). https://doi.org/10.1007/BF00296263

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  • DOI: https://doi.org/10.1007/BF00296263

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