Summary
UFT, a combination of the masked compound of 5-fluorouracil (FT-207) and uracil, was given to head and neck cancer patients for 1 week preoperatively and for 8 weeks postoperatively. Drug concentrations were examined in the surgically removed tissues. The concentrations of FT-207, 5-fluorouracil, and uracil were higher in tumor tissues than in normal tissues. The lymphocyte subpopulations were assessed by cytofluorometry with monoclonal antibodies. There was no evidence that adjuvant chemotherapy with UFT specifically suppresses immunocompetent cells. We therefore conclude that further clinical evaluation of adjuvant chemotherapy with UFT would be worthwhile.
Similar content being viewed by others
References
Fujii S, Ikenaka K, Fukushima M, Shirasaka T (1978) Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil. Cann 69:763
Fujii S, Kitano S, Ikenaga K, Shirasaka T (1979) Studies on coadministration of uracil or cytosine on antitumor activity of FT-207 or 5-FU derivatives. Jpn J Cancer Chemother 6:377
Inuyama Y, Fujii M, Mashino S, Tanaka J, Takaoka T, Kohno N (1983) Clinical effect of UFT therapy for head and neck cancer. Jpn J Cancer Chemother 10: 90
Kimura K, Isobe Y, Suga S, Suzuoki Y, Kondo C, Shimoyama M, Sakano T, Inoue K (1979) Enhancement of anticancer effects by change of drug formulation, with special reference to Oil Bleomycin, intrarectal use of FT-207, and combination of uracil and FT-207. Jpn J Cancer Chemother 6:237
Marunaka T, Umeno Y, Yoshida K, Nagamachi M, Minami Y, Fujii S (1980) High-pressure liquid chromatographic determination of Ftoraful [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus Ftoraful. J Pharm Sci 11:1296
Nakashima T, Matsumura Y, Nomura Y, Komiyama S, Makishima K, Hiroto I (1982) Antitumor effect of UFT against malignant tumors of maxillary sinus — Clinical and biochemical study. Jpn J Cancer Chemother 9:1729
Taguchi T, Nakano Y, Jikuya K, Fujii S, Ikenaka K, Fukushima M, Shirasaka T (1978a) Effect of uracil on the antitumor activity of Futraful. Jpn J Cancer Chemother 5:1161
Taguchi T, Nakano Y, Fujii S, Shirasaka T (1978b) Determination of 5-fluorouracil levels in tumors, blood, and other tissues. Jpn J Cancer Chemother 5:1167
Yamada Y, Toko T, Miyauchi S, Unemi N (1980) Effect of UFT on immune responses in mice. Cancer Chemother 7: 2134
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tachibana, M., Yasuda, N., Yoshimatsu, M. et al. UFT for head and neck cancers: its tissue concentrations and effects on lymphocyte subpopulations. Cancer Chemother. Pharmacol. 19, 65–68 (1987). https://doi.org/10.1007/BF00296259
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00296259