Summary
Serum Gm polymorphism was studied in 69 patients with liver cirrhosis, in 64 with liver cirrhosis plus hepatoma, in 40 with hepatoma without evidence of cirrhosis, and in 256 controls. The distribution of Gm factors in liver patients differed from that in the control group, this difference apparently being due to the distribution in cirrhosis patients negative for HBsAg and anti-HBs. Furthermore, significantly more heterozygous Gm individuals were found in this group of patients than in the control group. Thus it appears that Gm heterozygous individuals are prone to develop cryptogenic cirrhosis under the influence of other, as yet undetermined factors.
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References
Archimandritis A, Fertakis A, Stathopoulou R, Kalos A, Angelopoulos B (1975a) Distribution of Gm and Inv Factors in two samples of the Greek population. Acta Genet Med Gemellol (Roma) 24:329–331
Archimandritis A, Kalos A, Papakonstantinou G, Babionitakis A, Theodoropoulos G, Dimitriadis P (1975b) The Gm and Inv factors in rheumatoid arthritis Acta Genet Med Gemellol (Roma) 24:333–335
Billington BP (1956) A note on the distribution of AB0 blood groups in bronchiectasis and portal cirrhosis. Aust Ann Med 5:20–22
Fundeberg HH, Pink JRL, Stites DP, An-Chan Wang (1972) Basic immunogenetics. Oxford University Press, New York London Toronto
Grubb R (1970) The genetic markers of human immunoglobulins. Springer, Berlin Heidelberg New York
Hirayama C, Nakamura M, Koga S (1975) Serum haptoglobin type and liver cirrhosis. Humangenetik 28:139–146
Mereček Z., Hoenigova J (1970) Serum-Haptoglobintypen bei Leberkrankheiten. Experientia 26:1096–1097
Theodoropoulos G, Rigatos G, Babionitakis A, Archimandritis A, Fertakis A, Melissinos K (1977) Serum Gc system in liver cirrhosis and hepatoma. Hum Genet 39:225–228
Vyas GN, Shulman NR (1970) Hemagglutination assay for the antigen and anti-body associated with viral hepatitis. Science 170:332–333
Wewalka F (1960) Die Blutgruppen bei Lebercirrhosen. Blut 6:261–266
WHO (1965) Notation for genetic factors of human immunoglobulins. Bull WHO 33:721
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Theodoropoulos, G., Archimandritis, A., Drivas, G. et al. Serum Gm system in liver cirrhosis and hepatoma. Hum Genet 56, 217–219 (1980). https://doi.org/10.1007/BF00295698
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DOI: https://doi.org/10.1007/BF00295698