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Substrate affinity in PGM1, PGM2, and PGM3 isozymes

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Summary

An easy method for routine detection of PGM1, PGM2, and PGM3 isozymes is given. Differences in substrate affinity are discussed. Gene products pgm1 can be differentiated from gene products pgm3 by cofactor requirement.

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References

  • Bissbort S, Kömpf J, Bethge R, Gussmann S (1975) Population genetics of human red cell phosphoglucomutase isozymes PGM3 (E.C.: 2.7.5.1). Gene frequencies in Southwestern Germany. Hum Genet 27:57–58

    Google Scholar 

  • Barmann TE (1969) Enzyme handbook, vol I. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Douglas GR, McAlpine PJ, Hamerton JL (1973) Regional localization of loci for human PGM1 and 6-PGD on human chromosome 1 by using hybrids of Chinese hamster-human somatic cells. Proc Natl Acad Sci USA 70:2737–2740

    PubMed  Google Scholar 

  • Harris H, Hopkinson DA (1976) Handbook of enzyme electrophoresis in human genetics. North-Holland, Publishing Company, Amsterdam

    Google Scholar 

  • Jongsma A, Van Someren H, Westerveld A, Hagemeijer A, Pearson P (1973) Localization of genes on human chromosomes by studies of human-Chinese hamster somatic cell hybrids. Assignment of PGM3 to chromosome C 6 and regional mapping of the PGD, PGM1, and PEP C genes on chromosome A 1. Hum Genet 20:195–202

    Article  Google Scholar 

  • McAlpine PJ, Mohandas T, Hamerton JL (1975) Isozyme analysis of somatic cell hybrids: Assignment of the phosphoglucomutase2 (PGM2) gene locus to chromosome 4 in man with data on the molecular structure and human chromosome assignment of six additional markers. In: Isozymes, vol IV: Genetics and evolution. Academic Press, New York, p 149. Edited by CL Markert

    Google Scholar 

  • Nguyen Van Cong, Gillardon C, Picard JY, Feingold J Frézal J (1971) Liason probable (linkage) entre des locus PGM1 et Peptidase C chez l'homme. CR Acad Sci [D] (Paris) 272: 485–488

    Google Scholar 

  • Quick CB, Fisher RA, Harris H (1972) Differentiation of the PGM2 locus isozymes from those of PGM1 and PGM3 in forms of phosphoglucomutase activity. Ann Hum Genet 35:445–454

    PubMed  Google Scholar 

  • Siebert G, Ritter H, Kömpf J (1979) Mitochondrial malic enzyme (E.C. 1.1.1.40) in human leukocytes: formal genetics and population genetics. Hum Genet 51:319–322

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institut für Anthropologie und Humangenetik der Universität Tübingen, Wilhelmstraße 27, D-7400, Tübingen, Federal Republic of Germany

    G. Siebert, H. Ritter & J. Kömpf

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  1. G. Siebert
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  2. H. Ritter
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  3. J. Kömpf
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Siebert, G., Ritter, H. & Kömpf, J. Substrate affinity in PGM1, PGM2, and PGM3 isozymes. Hum Genet 56, 213–215 (1980). https://doi.org/10.1007/BF00295697

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  • DOI: https://doi.org/10.1007/BF00295697

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