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Abnormal cerebral cortical convolutions in an XYY fetus

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Summary

Because of maternal disease a pregnancy was electively terminated at 21 weeks of fetal gestation. At autopsy the fetus showed an abnormal pattern of cerebral cortical convolutions involving the frontal lobes. Karyotypic analysis revealed an XYY sex chromosome constitution. This observation, if confirmed in other XYY cases, raises the possibility that a developmental abnormality of the cerebral cortex may be involved in the higher-than-normal risk for behavioral disability exhibited by men with this genotype.

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Authors and Affiliations

  1. Department of Pathology, UCLA School of Medicine, 90024, Los Angeles, CA, USA

    Garth E. Austin & Robert S. Sparkes

  2. Department of Medicine, UCLA School of Medicine, 90024, Los Angeles, CA, USA

    Garth E. Austin & Robert S. Sparkes

Authors
  1. Garth E. Austin
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  2. Robert S. Sparkes
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Additional information

Supported in part by Grants HD-05615 and HD-04612 from The National Institute of Child Health and Human Development.

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Austin, G.E., Sparkes, R.S. Abnormal cerebral cortical convolutions in an XYY fetus. Hum Genet 56, 173–175 (1980). https://doi.org/10.1007/BF00295690

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  • DOI: https://doi.org/10.1007/BF00295690

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