Summary
Prominent intensely fluorescent satellites on one chromosome 22 seem to have been transferred, during gametogenesis of a male carrier of a balanced 10/22 translocation, from the normal 22 to the translocated 22 in his daughter and son, both carriers of the translocation. Prenatal diagnosis was performed in the carrier daughter and in the chromosomally normal female foetus the satellites have jumped back to one normal chromosome 22. The phenomenon is probably due to exchanges between the short arms of chromosome 22 at meiotic pairing in the father and in his daughter. These observations give a warning for caution in the use of marker variants for paternity tests and prenatal diagnosis.
References
Hamerton, J. J., Canning, N., Ray, M., Smith, S.: A cytogenetic survey of 14,069 newborn infants. Clin. Genet. 8, 223 (1975)
Hauge, M., Poulsen, H., Halberg, A., Mikkelsen, M.: The value of fluorescence markers in the distinction between maternal and fetal chromosomes. Humangenetik 26, 187 (1975)
Hultén, M., Lindsten, J.: The behaviour of structural aberrations at male meiosis. In: Human population cytogenetics, Patricia A. Jacobs, W. H. Price, Pamela Law, eds., p. 23. Edinburgh University Press 1970
Jonasson, J., Lindsten, J., Lundborg, R., Kissmeyer-Nielsen, F., Lamm, L. U., Bruun Petersen, G., Therkelsen, A. J.: HL-A antigens and heteromorphic fluorescence characters of chromosomes in prenatal paternity investigation. Nature (Lond.) 236, 312 (1972)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gimelli, G., Porro, E., Santi, F. et al. “Jumping” satellites in three generations: A warning for paternity tests and prenatal diagnosis. Hum Genet 34, 315–318 (1976). https://doi.org/10.1007/BF00295297
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00295297