Summary
Two patients with orbital or ocular adnexal neonatal hemangiomas were treated with intralesional injection of triamcinolone acetonide. Injection of steroids was started at 2 mg/kg twice a week. The doses of this drug were decreased gradually over a four week period. A dramatic reduction of the lesion was evident without a rebound phenomenon: however growth delay continued for only three months after therapy. No exact study of the storage of this compound in the tissue has been reported. The storage of triamcinolone acetonide was investigated for a period of up to 35 days in the tissue of rabbit backs. The 0 level of the residue was suggested to occur at about 60 days after injection of triamcinolone acetonide. In the two infants of the experimental study with strawberry-type nervus, the storage in the tissue of hemangioma was much higher than in rabbits. These results were comparable to the duration of the growth delay.
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Abe, S. Local steroid therapy of adnexal strawberry hemangioma in infants —long-term follow-up. Eur J Plast Surg 9, 29–35 (1986). https://doi.org/10.1007/BF00294794
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DOI: https://doi.org/10.1007/BF00294794