Summary
Mucous within the urinary bladder appears to play a protective role in shielding the uroepithelium against pathogens. This present study employs specific anti-mucous, antisera stabilization techniques to visualize a thin, continuous layer of mucous closely adherent to the human bladder uroepithelium, in both scanning and transmission electron microscopic analyses.
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Balish MJ, Jensen J, Uehling DT (1982) Bladder mucin: a scanning electron microscopy study in experimental cystitis. J Urol 128:1060
Cornish J, Lecamwasam JP, Harrison G, Vanderwee M, Miller TE (1988) Host defence mechanisms in the bladder 11 Disruption of the layer of mucous. Br J Exp Pathol 69:759
Cornish J, Vanderwee M, Miller T (1987) Mucous stabilization in the urinary bladder. Br J Exp Pathol 68:369
Dixon JS, Holm-Bentzen M, Gilpin CJ, Gosling JA, Bostofte E, Hald T, Larson S (1986) Electron microscopic investigation of the bladder urethelium and glycocalyx in patients with interstial cystitis. J Urol 135:621
Grabar P, Williams CA (1953) Methode permettant l'etude conjugee des proprietes electrophoretiques et immunochimiques d'un melange de proteines. Biochim Biophy Acta 10:193
Harrison G, Cornish J, Vanderwee M, Miller TE (1988) Host defence mechanisms in the bladder I role of mechanical factors. Br J Exp Pathol 69:245
Parsons CL, Schmidt JD, Pollen JJ (1983) Successful treatment of interstial cystitis with sodium pentosanpolysulfate. J Urol 130:51
Parsons CL, Schrom SH, Hanno PM, Mulholland SG (1978) Bladder surface mucin examination of possible mechanisms for its antibacterial effect. Invest Urol 16:196
Rozee KR, Cooper D, Lam K, Costerton JW (1982) Microbial flora of the mouse ileum mucous layer and epithelia surface. Appl Environ Microbiol 43:1451
Ruggieri MR, Levin RM, Hanno PM, Witkowski BA, Gill HS, Steinhardt GF (1988) Defective antiadherence activity of bladder extracts from patients with recurrent urinary tract infection. J Urol 140:157
Slomiany BL, Sarosiek J, Slomiany A (1987) Gastric mucous and the mucosal barrier. Dig Dis 5:125
Uehling DT (1988) What makes bacteria stick to the bladder mucosa? J Urol 140:156
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Cornish, J., Nickel, J.C., Vanderwee, M. et al. Ultrastructural visualization of human bladder mucous. Urol. Res. 18, 263–266 (1990). https://doi.org/10.1007/BF00294770
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DOI: https://doi.org/10.1007/BF00294770