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Acute neurological toxicity of intrathecal cytosine arabinoside

A case report

  • Original Articles
  • Neurotoxicity
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Summary

A patient developed severe neurological toxicity, with peripheral and cerebral components and hyponatraemia following one intrathecal injection of 80 mg cytosine arabinoside. The severity of his symptoms may reflect heavy prior neurotoxic chemotherapy.

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Authors and Affiliations

  1. Cancer Research Campaign Laboratories, Department of Medical Oncology, Charing Cross and Westminster Medical School, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, England

    S. Michael Crawford, Gordon J. S. Rustin & Kenneth D. Bagshawe

Authors
  1. S. Michael Crawford
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  2. Gordon J. S. Rustin
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  3. Kenneth D. Bagshawe
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Crawford, S.M., Rustin, G.J.S. & Bagshawe, K.D. Acute neurological toxicity of intrathecal cytosine arabinoside. Cancer Chemother. Pharmacol. 16, 306–307 (1986). https://doi.org/10.1007/BF00293998

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  • DOI: https://doi.org/10.1007/BF00293998

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