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Polymeric reagents: preparation and characterization of novel solid-phase, silylating agents derived from copolymers containing 4-[3′-(dimethyl phenyl silyl)-propyl]-styrene

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Summary

Two novel reactive polymers useful as protecting groups for hydroxyls have been prepared by copolymerization of a silicon containing monomer, 4-[3′-(dimethyl phenyl silyl)-propyl]-styrene, with styrene and divinylbenzene, followed by chemical modification of the resulting insoluble polymer beads. The polymeric reagents containing trialkylsilyl chloride or trialkylsilyl trifluoroacetate moieties are effective for the protection of alcohols and a procedure for their facile regeneration is described.

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Author notes

  1. Harald D. H. Stöver

    Present address: Dept. of Chemistry, McMaster University, Hamilton, Ontario, Canada

  2. Pei-Zhi Lü

    Present address: Chengdu Institute of Organic Chemistry, Chengdu, China

Authors and Affiliations

  1. Department of Chemistry, Cornell University, Baker Laboratory, 14853, Ithaca, NY, USA

    Harald D. H. Stöver, Pei-Zhi Lü & Jean M. J. Fréchet

  2. Department of Chemistry, University of Ottawa, K1N 9B4, Ottawa, Ontario, Canada

    Harald D. H. Stöver, Pei-Zhi Lü & Jean M. J. Fréchet

Authors
  1. Harald D. H. Stöver
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  2. Pei-Zhi Lü
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  3. Jean M. J. Fréchet
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Stöver, H.D.H., Lü, PZ. & Fréchet, J.M.J. Polymeric reagents: preparation and characterization of novel solid-phase, silylating agents derived from copolymers containing 4-[3′-(dimethyl phenyl silyl)-propyl]-styrene. Polymer Bulletin 25, 575–582 (1991). https://doi.org/10.1007/BF00293517

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  • DOI: https://doi.org/10.1007/BF00293517

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