A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the IGF-I gene is located on chromosome 12. Comparison of the chromosomal assignments of the IGF-I gene and two other members of the insulin gene family, with three c-ras oncogenes, reveals a remarkable association of the two gene families.
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Höppener, J.W.M., de Pagter-Holthuizen, P., van Kessel, A.H.M.G. et al. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum Genet 69, 157–160 (1985). https://doi.org/10.1007/BF00293288
- Growth Factor
- Internal Medicine
- Gene Family
- Metabolic Disease
- Somatic Cell