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The human gene encoding insulin-like growth factor I is located on chromosome 12

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Summary

A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot hybridization analysis of DNA from human-Chinese hamster somatic cell hybrids showed that the IGF-I gene is located on chromosome 12. Comparison of the chromosomal assignments of the IGF-I gene and two other members of the insulin gene family, with three c-ras oncogenes, reveals a remarkable association of the two gene families.

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References

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Authors and Affiliations

  1. Laboratory for Physiological Chemistry, State University of Utrecht, The Netherlands

    P. de Pagter-Holthuizen & J. S. Sussenbach

  2. Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands

    A. H. M. Geurts van Kessel

  3. Department of Pediatrics, State University of Utrecht, Utrecht, The Netherlands

    M. Jansen

  4. Department of Pediatrics, Johns Hopkins University, School of Medicine, 21205, Baltimore, MD, USA

    S. D. Kittur & S. E. Antonarakis

  5. Department of Internal Medicine, State University Hospital, State University of Utrecht, Utrecht, The Netherlands

    C. J. M. Lips

  6. Institute of Molecular Biology, State University of Utrecht, 8 Padualaan, 3584 CH, Utrecht, The Netherlands

    J. W. M. Höppener

Authors
  1. J. W. M. Höppener
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  2. P. de Pagter-Holthuizen
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  3. A. H. M. Geurts van Kessel
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  4. M. Jansen
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  5. S. D. Kittur
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  6. S. E. Antonarakis
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  7. C. J. M. Lips
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  8. J. S. Sussenbach
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Höppener, J.W.M., de Pagter-Holthuizen, P., van Kessel, A.H.M.G. et al. The human gene encoding insulin-like growth factor I is located on chromosome 12. Hum Genet 69, 157–160 (1985). https://doi.org/10.1007/BF00293288

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  • DOI: https://doi.org/10.1007/BF00293288

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