Molecular and General Genetics MGG

, Volume 125, Issue 1, pp 91–98 | Cite as

Extrachromosomal inheritance of paromomycin resistance in Saccharomyces cerevisiae

Genetic and biochemical characterization of mutants
  • Regina Kutzleb
  • Rudolf J. Schweyen
  • Fritz Kaudewitz


In Saccharomyces cerevisiae, mutants were isolated which show high resistance to the aminoglycoside paromomycin. Amino acid incorporation of mitochondria isolated from such mutant strains proved also to be paromomycin resistant. All of them are cross-resistant to the structurally related antibiotic neomycin. Three independent methods revealed the resistance to be extrachromosomally, presumably mitochondrially inherited.


Saccharomyces Cerevisiae Saccharomyces Mutant Strain High Resistance Aminoglycoside 
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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • Regina Kutzleb
    • 1
  • Rudolf J. Schweyen
    • 1
  • Fritz Kaudewitz
    • 1
  1. 1.Institut für Genetik der Universität MünchenMunchenGermany

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