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Molecular structure of the lampbrush loops nooses of the Y chromosome of Drosophila hydei

I. The Y chromosome-specific repetitive DNA sequence family ay1 is dispersed in the loop DNA

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Abstract

The molecular structure of the lampbrush loopforming fertility gene nooses from the short arm of the Y chromosome of Drosophila hydei is described on the basis of cloned DNA sequences which are characteristic for the sequence organization in the lampbrush loop. Y chromosomal lampbrush loops are organized into tandem repeat clusters of loop-specific repetitive DNA sequences and in interspersed repetitive DNA sequences with homologies elsewhere in the genome. In this paper, the basic properties of a repeat unit of the tandemly repeated sequence family ay1 are described. Moreover, it is shown that a loop contains several different domains carrying repeat clusters of the same repeated DNA family but with divergent sequence character. One of these clusters is characterized by an internal duplication of the basic repeat unit. We propose that the tandem repeat DNA family ay1 forms a “frame” of the lampbrush loop which is required for structural and functional reasons.

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Author notes

  1. Peter Vogt

    Present address: Institut für Anthropologie und Humangenetik, Universität Heidelberg, Im Neuenheimer Feld 328, D-6900, Heidelberg 1, Federal Republic of Germany

Authors and Affiliations

  1. Department of Genetics, Faculty of Science, University of Nijmegen, Toernooiveld, NL-6525, ED Nijmegen, The Netherlands

    Peter Vogt & Wolfgang Hennig

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  1. Peter Vogt
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  2. Wolfgang Hennig
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Vogt, P., Hennig, W. Molecular structure of the lampbrush loops nooses of the Y chromosome of Drosophila hydei . Chromosoma 94, 449–458 (1986). https://doi.org/10.1007/BF00292754

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  • DOI: https://doi.org/10.1007/BF00292754

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