Abstract
We assessed the feasibility of SPECT imaging with 201Tl-diethyldithiocarbamate (201Tl-DDC), a new cerebral blood flow tracer with little redistribution, expecting to observe less extensive redistribution than with 201Tl-chloride. Myocardial sections were obtained in three patients presenting with documented coronary artery disease and injected at peak exercise with 100 MBq 201Tl-DDC. In two patients there was a clear redistribution phenomenon at four h after injection. In cultured myocardial cells of newborn rats, the uptake and washout of 201Tl-chloride and 201Tl-DDC were compared. The 201Tl-DDC uptake was lower than 201Tl-chloride (transmembrane gradients were respectively 89±10 and 4.1±0.2, mean±sem, n=14, P<0.001). After 2 h washout in a Tl free medium, the retention of 201Tl-chloride in the cells was 4% vs 19% for 201Tl-DDC. It is concluded that although myocardial imaging is feasible with 201Tl-DDC, this agent redistributes significantly with time.
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Maublant, J.C., Moins, N., Van Royen, E.A. et al. Myocardial uptake of thallium-201 diethyldithiocarbamate (201TI-DDC) in cultured heart cells and in humans. Eur J Nucl Med 13, 408–409 (1987). https://doi.org/10.1007/BF00292493
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DOI: https://doi.org/10.1007/BF00292493