Cancer Chemotherapy and Pharmacology

, Volume 23, Issue 5, pp 329–330 | Cite as

Severe renal failure following high-dose ifosfamide and mesna

  • Pax H. B. Willemse
  • Paul E. de Jong
  • Job B. Elema
  • Nanno H. Mulder
Original Articles Ifosfamide, Renal Function, Mesna


A 62-year-old woman developed subacute renal failure after the repeated administration of ifosfamide (IFX), despite its combination with continuous sodium 2-mercaptoethane sulfonate (mesna) infusion. Biopsy findings, the possible underlying mechanism, and the existing literature are discussed.


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Pax H. B. Willemse
    • 1
  • Paul E. de Jong
    • 2
  • Job B. Elema
    • 3
  • Nanno H. Mulder
    • 1
  1. 1.Department of Internal Medicine, Division of Medical OncologyUniversity HospitalGroningenThe Netherlands
  2. 2.Department of NephrologyUniversity HospitalGroningenThe Netherlands
  3. 3.Department of PathologyUniversity HospitalGroningenThe Netherlands

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