Die Korrelation von Blutgruppenantigenen und-substanzen mit hypertonischer Erkrankung

Abstract

We have investigated in 383 hypertonics, 151 males and 232 females, the AB0 blood groups, secretion of blood group substances AB0 (H), Rh₀ (D) factor, M and N groups and haptoglobin groups in the serum.

Most patients were 40–50 years old and older, suffering from a fixed arterial hypertension with a diastolic blood pressure not lower than 110 mm Hg. All patients with renal, matabolic or nervous disorders were excluded from our series.

In comparison with normal values in Czechoslovak population a significantly lower percentage was ascertained of nonsecretors of group substances in both sexes of B group hypertonics. In 72 persons of group B there were 8 nonsecretors i.e. 11.11% as compared with 37.84% nonsecretors in normal population; for 1 degree of freedom P < 0.001, for 4 degrees of freedom P < 0.05.

Furthermore, in male hypertonics a preponderance of 0 over A, in female hypertonics that of A over 0 were ascertained. There were 39.07% male hypertonics of blood group 0 in comparison with 33.25% of group 0 in normal population and 28.88% in female hypertonics.

In males hypertonics the blood group A appeared in 33.11%, the normal values being 40.79% and the incidence in females hypertonics being 45.26%.

These differences achieved statistically significant values only in mutual comparison of the male and female group of hypertonics.

In distribution of characters M/N and haptoglobin types no deviations from normal values were observed.