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An inherited α1-antitrypsin variant

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Abstract

The pedigree of a family some of whose members are heterozygous for an electrophoretically slower α1-antitrypsin variant is reported. Linkage relations to other common genetic markers have not been found.

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References

  • Axelsson, U., and C.-B. Laurell: Hereditary variants of serum α1-antitrypsin. Amer. J. hum. Genet. 17, 466–472 (1965).

    Google Scholar 

  • Briscoe, W. A., F. Kueppers, A. L. Davis, and A. G. Bearn: A case of inherited α1-antitrypsin deficiency associated with pulmonary emphysema. Amer. Rev. Resp. Dis. 94, 529–539 (1966).

    Google Scholar 

  • Eriksson, S.: Studies in α1-antitrypsin deficiency. Suppl. to Actamed. scand. 175, 38–39 (1965).

    Google Scholar 

  • Kitchin, F. D.: Demonstration of the inherited serum group specificprotein by acrylamide electrophoresis. Proc. Soc. exp. Biol. (N. Y.) 119, 1153–1155 (1965).

    Google Scholar 

  • Kueppers, F., W. A. Briscoe, and A. G. Bearn: Hereditary deficiency of serum α1-antitrypsin. Science 146, 1678–1679 (1964).

    Google Scholar 

  • —: Inherited variations of human serum α1-antitrypsin. Science 154, 407–408 (1966).

    Google Scholar 

  • Laurell, C.-B.: Antigen-antibody crossed electrophoresis Anal. Biochem. 10, 358–361 (1965a).

    Google Scholar 

  • —: Effect of neuraminidase, acetone and chloroform on α1-antitrypsin. Scand. J. clin. Lab. Invest. 17, 297–298 (1965b).

    Google Scholar 

  • Race, R. R., and R. Sanger: Blood groups in man. 4. ed, p. 135–200. Oxford: Blackwell Scie. Publ. 1962.

    Google Scholar 

  • Rosenfield, R. E., F. H. Allen Jr. S. N. Swisher, and S. Kochwa: A review of Rheology and presentation of a new terminology. Transfusion (Philad.) 2, 287–312 (1962).

    Google Scholar 

  • Smithies, O.: An improved procedure for starch-gel electrophoresis: Further variations in the serum proteins of normal individuals. Biochem. J. 71, 585–587 (1959).

    Google Scholar 

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Authors and Affiliations

  1. The Rockefeller University, New York, N. Y.

    Friedrich Kueppers & Alexander G. Bearn

  2. Cardiovascular Research Institute, University of California San Francisco Medical Center, 94122, San Francisco, California, USA

    Friedrich Kueppers

Authors
  1. Friedrich Kueppers
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  2. Alexander G. Bearn
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Kueppers, F., Bearn, A.G. An inherited α1-antitrypsin variant. Hum Genet 4, 217–220 (1967). https://doi.org/10.1007/BF00292195

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  • DOI: https://doi.org/10.1007/BF00292195

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