Abstract
Six distinct Y Chromosomes (Chr) were identified among 39 standard inbred strains of mice with five probes that identified Y Chr-specific restriction fragments on Southern blots. Three Y Chr types, distributed among 31 strains, were of Asian Mus musculus origin. The remaining three Y Chr types, distributed among eight strains, were of M. domesticus origin. The Asian source of the M. musculus Y Chr was confirmed by determining the DNA sequence of 221 bp from an open reading frame within the Sry (sex determining region Y) gene (Gubbay et al., Nature 346 245–250, 1990) in three inbred strains (C57BL/6J, AKR/J, and SWR/J) and comparing the sequence to the homologous sequences derived from wild caught European and Asian M. musculus males. These data indicate that a minimum of six male mice contributed to the formation of the old inbred strains.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allard, M.W., Ellsworth, D.L., and Honeycutt, R.L.: The production of single-stranded DNA suitable for sequencing using the polymerase chain reaction. Biotechniques 10: 24–26, 1991.
Altschul, S.F. and Ericson, B.W.: Optimal sequence alignment using affine gap. Bull Math Biol 48: 603–616, 1986.
Artzt, K., Barlow, D., Dove, W.F., Fischer-Lindahl, K., Klein, J., Lyon, M.F., and Silver, L.M.: Maps of mouse Chromosome 17: first report. Mammalian Genome 1: 5–29, 1991.
Atchley, W.R. and Fitch, W.M.: Gene trees and the origins of inbred strains of mice. Science 254: 554–558, 1991.
Bishop, C.E., Boursot, P., Baron, B., Bonhomme, F., and Hatat, D.: Most classical Mus musculus laboratory mouse strains carry a Mus musculus musculus Y chromosome. Nature 315: 70–73, 1985.
Blank, R.D., Campbell, G.R., and D'Eustachio, P.: Possible derivation of the laboratory mouse genome from multiple wild Mus species. Genetics 114: 1257–1269, 1986.
Bonhomme, F.: Evolutionary relationships in the genus Mus. Curr Top Microbiol Immunol 127: 19–34, 1986.
Bonhomme, F., Britton-Davidian, J., Thaler, L., Chapman, V.M., Moriwaki, K., Nevo, E., and Thaler, L.: Biochemical diversity and evolution in the genus Mus. Biochem Genet 22: 275–303, 1986.
Bonhomme, F., Miyashita, N., Boursot, P., Catalan, J., and Moriwaki, K.: Genetical variation and polyphyletic origin in Japanese Mus musculus. Heridity 63: 299–308, 1989.
Bosselman, R.A., van Straaten, F., Van Beveren, C., Verma, I.M., and Vogl, M.: Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA. J Virol 44: 19–31, 1982.
Buckler, C.E., Hoggan, M.D., Chan, H.W., Sears, J.F., Khan, A.S., Moore, J.L., Hartley, J.W., Rowe, W.P., and Martin, M.A.: Cloning and characterization of an envelope-specific probe from xenotropic murine leukemia proviral DNA. J Virol 41: 228–236, 1982.
Eicher, E.M., Hutchinson, K.W., Phillips, S.J., Tucker, P.K., and Lee, B.K.: A repeated segment on the mouse Y chromosome is composed of retroviral-related, Y-enriched, and Y-specific sequences. Genetics 122: 181–192, 1989.
Ferris, S.D., Sage, R.D., and Wilson, A.C.: Evidence from mtDNA sequences that common laboratory strains of inbred mice are descended from a single female. Nature 295: 163–165, 1982.
Ferris, S.D., Sage, R.D., Prager, E.M., Ritte, U., and Wilson, A.C.: Mitochondrial DNA evolution in mice. Genetics 105: 681–721, 1983a.
Ferris, S.D., Sage, R.D., Huang, C.-M., Nielsen, J.T., Ritte, U., and Wilson, A.C.: Flow of mitochondrial DNA across a species boundary. Proc Natl Acad Sci USA 80: 2290–2294, 1983b.
Festing, M.F.W. and Lovell, D.P.: Domestication and development of the mouse as a laboratory animal. Symp Zool Soc Lond 47: 43–62, 1981.
Gubbay, J., Collignon, J., Koopman, P., Capel, B., Economou, A., Munsterberg, A., Vivian, N., Goodfellow, P., and Lovell-Badge, R.: A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature 346: 245–250, 1990.
Hunt, W.G. and Selander, R.K.: Biochemical genetics of hybridisation in European mice. Heredity 31: 11–33, 1973.
International Code of Zoological Nomenclature, University of California Press, Berkeley, 1985.
Keeler, C.E.: The Laboratory Mouse, pp. 1–81, Harvard University Press, Cambridge, 1931.
Lamar, E.E. and Palmer, E.: Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains. Cell 37: 171–177, 1984.
Lathrop, A.E.C. and Loeb, L.: Further investigations on the origin of tumors in mice. J Exp Med 22: 646–673, 1915.
Little, C.C. and Bagg, H.J.: the occurrence of four inheritable morphological variations in mice and their possible relation to treatment with X-rays. J Exp Zool 41: 45–91, 1924.
Lynch, C.J.: The so-called Swiss mouse. Lab Animal Care 19: 214–220, 1969.
Maniatis, T., Fritsch, E.F., and Sambrook, J.: Molecular Cloning: a Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1982.
Moriwaki, K., Miyashita, N., Suzuki, H., Kurihara, Y., and Yonekawa, H.: Genetic features of major geographical isolates of Mus musculus. Curr Top Microbiol Immunol 127: 55–61, 1986.
Morse, H.C. III: Introduction. In H.C. Morse, III (ed.): Origins of Inbred Mice, pp. 3–21, Academic Press, New York, 1978.
Morse, H.C. III: The laboratory mouse—a historical perspective. In H.L. Foster, J.D. Small, and J.G. Fox (eds.): The Mouse in Biochemical Research Vol. I., pp. 1–16, Academic Press, New York, 1981.
Nishioka, Y.: Y-chromosomal DNA polymorphism in mouse inbred strains? Genet Res 50: 69–72, 1987.
Nishioka, Y. and Lamothe, E.: Isolation and characterization of a mouse Y chromosomal repetitive sequence. Genetics 113: 417–432, 1986.
O'Neill, R.R., Khan, A.S., Hoggan, M.D., Hartley, J.W., Martin, M.A., and Repaske, R.: Specific hybridization probes demonstrate more MCF than xenotropic MuLV env related sequences in DNAs from inbred laboratory mice. J Virol 58: 359–366, 1986.
Potter, M.: Comments on the relationship of inbred strains to the genus Mus. In H.C. Morse, III (ed.); Origins of Inbred Mice, pp. 497–509, Academic Press, New York, 1978.
Sage, R.D., Whitney III, J.B., and Wilson, A.C.: Genetic analysis of a hybrid zone between domesticus and musculus mice (Mus musculus complex): hemoglobin polymorphisms. Curr Top Microbiol Immunol 127: 75–85, 1986a.
Sage, R.D., Heyneman, D., Lim, K.-C., and Wilson, A.C.: Wormy mice in a hybrid zone. Nature 324: 60–63, 1986b.
Saiki, R.K., Scharf, S., Faloona, F., Mullis, K.B., Horn, G.T., Erlich, A., and Arnheim, N.: Enzymatic amplification of B-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230: 1350–1354, 1985.
Sanger, F., Nicklen, S., and Coulson, A.R.: DNA sequencing with chain terminating inhibitors. Proc Natl Acad Sci USA 74: 5463–5467, 1977.
Strong, L.C.: The origin of some inbred mice. Cancer Res 2: 531–539, 1942.
Swofford, D.L.: PAUP version 2.4, Illinois Natural History Survey, Champaign, Ill., 1985.
Tucker, P.K., Lee, B.K., and Eicher, E.M.: Y chromosome evolution in the subgenus Mus (genus Mus). Genetics 122: 169–179, 1989.
Tucker, P.K., Sage, R.D., Warner, J.H., Wilson, A.C., and Eicher, E.M.: Abrupt cline for sex chromosomes in a hybrid zone between two species of mice. Evolution, in press, 1992.
Vanlerberghe, F., Dod, B., Boursot, P., Bellis, M., and Bonhomme, F.: Absence of Y-chromosome introgression across the hybrid zone between Mus musculus domesticus and Mus musculus musculus. Genet Res 48: 191–197, 1986.
Vanlerberghe, F., Boursot, P., Nielsen, J.T., and Bonhomme, F.: A steep cline for mitochondrial DNA in Danish mice. Genet Res 52: 185–193, 1988a.
Vanlerberghe, F., Boursot, P., Catalan, J., Gerasimov, S., Bonhomme, F., Botev, B.A., and Thaler, L.: Analyse genetique de la zone d'hydbridation entre les deux sous-especes de souris Mus musculus domesticus et Mus musculus musculus en Bulgarie. Genome 30: 427–437, 1988b.
Yonekawa, H., Moriwaki, K., Gotoh, O., Wantanabe, J., Hayashi, J.-I., Miyashita, N., Petras, M.L., and Tagashira, Y.: Relationship between laboratory mice and the subspecies Mus musculus domesticus based on restriction endonuclease cleavage patterns of mitochondrial DNA. Jpn J Genet 55: 289–296, 1980.
Yonekawa, H., Moriwaki, K., Gotoh, O., Miyashita, N., Migita, S., Bonhomme, F., Hjorth, J.P., Petras, M.L., and Tagashira, Y.: Origins of laboratory mice deduced from restriction patterns of mitochondrial DNA. Differentiation 22: 222–226, 1982.
Yonekawa, H., Gotoh, O., Tagashira, Y., Matsushima, Y., Shi, L.-I., Cho, W.S., Miyashita, N., and Moriwaki, K.: A hybrid origin of Japanese mice “Mus musculus molossinus”. Curr Top Microbiol Immunol 127: 62–67, 1986.
Yonekawa, H., Moriwaki, K., Gotoh, O., Miyashita, N., Matsushima, Y., Liming, S., Cho, W.S., Xiao-Lan, Z., and Tagashira, Y.: Hybrid origin of Japanese mice: “Mus musculus molossinus”: evidence from restriction analysis of mitochondrial DNA. Mol Biol Evol 5: 63–78, 1988.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tucker, P.K., Lee, B.K., Lundrigan, B.L. et al. Geographic origin of the Y Chromosomes in “old” inbred strains of mice. Mammalian Genome 3, 254–261 (1992). https://doi.org/10.1007/BF00292153
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00292153