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Confirmation of the influence of a Chromosome 7 locus on susceptibility to audiogenic seizures

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Abstract

Mouse strain differences in susceptibility to audiogenic seizures (AGS) are due to allelic differences at multiple genetic loci. Three loci that influence susceptibility to AGS have been mapped on Chromosomes (Chr) 12, 4, and 7 (Asp-1, Asp-2, and Asp-3, respectively). Here we report evidence that confirms linkage of Asp-3 to c on Chr 7 and parental effects on AGS susceptibility, but not genomic imprinting of Asp-3.

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Authors and Affiliations

  1. Department of Neurology, Children's Hospital and Harvard Medical School, 300 Longwood Avenue, 02115, Boston, Massachusetts, USA

    Paul E. Neumann

  2. The Jackson Laboratory, 04609, Bar Harbor, Maine, USA

    Robert L. Collins

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  1. Paul E. Neumann
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  2. Robert L. Collins
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Neumann, P.E., Collins, R.L. Confirmation of the influence of a Chromosome 7 locus on susceptibility to audiogenic seizures. Mammalian Genome 3, 250–253 (1992). https://doi.org/10.1007/BF00292152

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  • DOI: https://doi.org/10.1007/BF00292152

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