Summary
Tyrosine aminotransferase (TAT; EC 2.6.1.5) is a liver enzyme involved in amino acid metabolism and gluconeogenesis. Low levels of TAT have been implicated in several inherited disorders, particularly tyrosinemia II (Richner-Hanhart syndrome). We have determined the chromosomal location of the human TAT gene by Southern blot hybridization analysis of DNAs from 18 humanxrodent hybrid cell lines, using a rat cDNA probe. The results indicate that the TAT gene maps to chromosome 16. Analysis of two hybrids containing a rearranged chromosome 16 allowed assignment of the TAT locus to 16q22→24. In situ hybridization to human metaphase chromosomes confirmed this regional assignment.
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Barton, D.E., Yang-Feng, T.L. & Francke, U. The human tyrosine aminotransferase gene mapped to the long arm of chromosome 16 (region 16q22→q24) by somatic cell hybrid analysis and in situ hybridization. Hum Genet 72, 221–224 (1986). https://doi.org/10.1007/BF00291881
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DOI: https://doi.org/10.1007/BF00291881