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Mutations for the autosomal recessive and autosomal dominant forms of polycystic kidney disease are not allelic

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Summary

The autosomal dominant form of polycystic kidney disease (ADPKD) has been linked to the α-globin gene locus on 16p. Linkage studies between the autosomal recessive type (ARPKD) and the 3′ HVR of the α-globin gene cluster showed that the ARPKD and ADPKD are not allelic.

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Authors and Affiliations

  1. MRC Human Ecogenetics Research Unit, Department of Human Genetics, School of Pathology, South African Institute for Medical Research and University of Medicine, P.O. Box 1038, Johannesburg, South Africa

    Michèle Ramsay & Trefor Jenkins

  2. Nuffield Department of Medicine, John Radeliffe Hospital, Oxford, UK

    Stephen T. Reeders & Ordan J. Lehmann

  3. Department of Paediatrics and Child Health, Johannesburg Hospital, Johannesburg, South Africa

    Peter D. Thomson & Lawrence S. Milner

  4. Section of Medical Genetics, University Hospital of Wales, Heath Park, Cardiff, UK

    L. Lazarou

  5. Institute of Child Health, University of London, 30 Guilford Street, London, UK

    Thomas M. Barratt & Adrian Yau

Authors
  1. Michèle Ramsay
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  2. Stephen T. Reeders
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  3. Peter D. Thomson
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  4. Lawrence S. Milner
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  5. L. Lazarou
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  6. Thomas M. Barratt
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  7. Adrian Yau
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  8. Ordan J. Lehmann
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  9. Trefor Jenkins
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Ramsay, M., Reeders, S.T., Thomson, P.D. et al. Mutations for the autosomal recessive and autosomal dominant forms of polycystic kidney disease are not allelic. Hum Genet 79, 73–75 (1988). https://doi.org/10.1007/BF00291714

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  • DOI: https://doi.org/10.1007/BF00291714

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