Skip to main content
SpringerLink
Log in

Mutagenicity of isoniazid: Testing for somatic chromosome aberrations in mouse embryos

  • Original Investigations
  • Published:
Human Genetics Aims and scope Submit manuscript

Summary

Isonicotinic acid hydrazide (INH) were given by peroral intubation to pregnant mice of strain C57BL/6Ffm on day 9 of pregnancy, INH was given in the following doses: 0, 5, 25, and 125 mg/kg solved in physiological saline. Cytogenetic analysis of homogenized embryos 6, 12, 24, and 48 h, resp., after treatment of the females did not show any increase of the rate of gaps or chromosomal aberrations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Krauth, I.: A locally most powerful tied rank test in a Wilcoxon situation. Ann. Math. Stat. 42, 1949–1956 (1971)

    Google Scholar 

  • Roux, C., Emerit, I., Taillemite, J. L.: Chromosomal breakage and teratogenesis. Teratology 4, 303–316 (1971)

    Google Scholar 

  • Soukup, S. W., Takacs, E., Warkany, J.: Chromosome changes in rat embryos following X-irradiation. Cytogenetics 4, 130–144 (1965)

    Google Scholar 

  • Stucky, W., Vollmar, J.: Exact probabilities for tied linear rank tests. J. Statist. Comput. Simul. 5, 73–81 (1976)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Humangenetik, Klinikum der J.-W.-Goethe-Universität Frankfurt, D-6000, Frankfurt/Main, Federal Republic of Germany

    Jürgen Fränz

Authors
  1. Jürgen Fränz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fränz, J. Mutagenicity of isoniazid: Testing for somatic chromosome aberrations in mouse embryos. Hum Genet 42, 28–30 (1978). https://doi.org/10.1007/BF00291620

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00291620

Keywords

Search

Navigation