Summary
100 mg INH/kg body weight was administered to male Wistar rats five times, at 24 h intervals, either intraperitoneally or intravenously. In both experimental series the yield of chromosome aberrations in bone marrow cells was not increased as compared to controls.
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Reference
Cirnu-Georgian, L., Lenghel, V.: Ioniazid-induced chromosome aberrations. Lancet 1971 II, 93
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Basler, A. Analysis of chromosome aberrations in bone marrow cells of rats after treatment with isoniazid. Hum Genet 42, 26–27 (1978). https://doi.org/10.1007/BF00291619
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DOI: https://doi.org/10.1007/BF00291619