Summary
Two hundred and one unrelated French Basque individuals were studied for HLA-A, B, C, DR and Bf polymorphisms. The results show that the Bf S0.7 (Bf S1) variant, which is known to be associated with HLA-Bw21, presents a highly significant linkage disequilibrium with a subtypic specificity, i.e., Bw50 (Δ=0.0123, ΔS=100%, P<10−8). As neither Bf S0.7 variant nor Bw50 antigen is found in Mongoloid populations, it is suggested that in evolutionary terms, the Bf S0.7 mutation is a more recent event than the HLA-Bw21 split.
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Ohayon, E., de Mouzon, A., Hauptmann, G. et al. Genetic linkage between Bf S0.7 (Bf S1) and HLA-Bw50. Hum Genet 54, 417–418 (1980). https://doi.org/10.1007/BF00291591
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DOI: https://doi.org/10.1007/BF00291591