Summary
This study contains data obtained from a cytogenetic investigation of six patients with acute and chronic leukaemia. The karyotypes of bone marrow or blood cells of these patients showed a partial or complete trisomy for the long arm of chromosome 1. Three observations revealed a pronounced resistance of cell clones with 1q+towards cytostatic therapy, and a comparatively short life span of patients after detection of 1q+. The importance of these changes for the role of some chromosomes and chromosome loci in leukaemogenesis is discussed.
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Mamaeva, S.E., Mamaev, N.N., Jartseva, N.M. et al. Complete or partial trisomy for the long arm of chromosome 1 in patients with various hematologic malignancies. Hum Genet 63, 107–112 (1983). https://doi.org/10.1007/BF00291527
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DOI: https://doi.org/10.1007/BF00291527