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Frequency of satellite association in individuals with structural abnormalities of nucleolus organiser region

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Summary

The frequency of involvement of acrocentric chromosomes into satellite association has been extensively studied in recent years. These studies have aimed to show the existence of a relationship between satellite association, centric fusion and non-disjunction. In the present paper, evidence is given that different D-group chromosomes all bearing structural abnormalities in the nucleolus organizer region are preferentially involved in satellite association. Some interpretations of this finding are discussed.

Zusammenfassung

Die Häufigkeit der Beteiligung akrozentrischer Chromosomen bei Satellitenassoziation ist in den letzten Jahren eingehend untersucht worden. Diese Untersuchungen hatten zum Ziel, die Beziehungen zwischen Satellitenassoziation, zentrischer Fusion und Non-disjunction aufzuzeigen. Hier könnte dargelegt werden, daß verschiedene D-Chromosomen, die einen Defekt in der Region des Nucleolus-Organisators haben, bevorzugt an der Satellitenassoziation beteiligt sind. Erklärungen dieser Befunde werden diskutiert.

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References

  • Cooke, P.: Non random participation of chromosome 13, 14 and 15 in acrocentric associations. Humangenetik 13, 309–314 (1971).

    Google Scholar 

  • Cooper, H. L., Hirschhorn, K.: Enlarged satellites as a familial chromosome marker. Amer. J. hum. Genet. 14, 107–124 (1962).

    Google Scholar 

  • Court Brown, W. M.: Human population cytogenetics, pp 22–23. Amsterdam: North-Holland Publ. 1967.

    Google Scholar 

  • Cuevas-Sosa, A.: Human chromosomology: random association of acrocentrics. Genetica 41, 626–634 (1970).

    Google Scholar 

  • De Capoa, A., Rocchi, A.: Autoradiographic identification of a 13/21 translocation. Cytogenetics 9, 396–400 (1970).

    Google Scholar 

  • Ferguson-Smith, M. A.: The sites of nucleolus formation in human pachytene chromosomes. Cytogenetics 3, 124–134 (1964).

    Google Scholar 

  • Ferguson-Smith, M. A., Handmaker, S. D.: Observations on the satellited human chromosomes. Lancet 1961 a I, 638–640.

  • Ferguson-Smith, M. A., Handmaker, S. D.: Observations on the satellited human chromosomes. Lancet 1961b II, 1362.

  • Giannelli, F., Howlett, R. M.: The identification of the chromosomes of the D group (13–15 Denver): an autoradiographic and measurement study. Cytogenetics 5, 186–205 (1966).

    Google Scholar 

  • Gigliani, F., de Capoa, A., Rocchi, A.: A marker chromosome number 14 with double satellite observed in two generations: an unbalanced chromosome constitution associated with normal phenotype. Humangenetik 15, 191–195 (1972).

    Google Scholar 

  • Hamerton, J. L.: Human cytogenetics (clinical cytogenetics) pp. 259–260. New York-London: Academic Press 1971.

    Google Scholar 

  • Hamerton, J. L., Giannelli, F., Polani, P. E.: Cytogenetics of Down's syndrome (mongolism). I. Data on a consecutive series of patients referred for genetic conselling and diagnosis. Cytogenetics 4, 171–185 (1965).

    Google Scholar 

  • Nakagome, Y.: DNA replication studies of human D-group chromosomes in satellite associations. Cytogenetics 8, 296–303 (1969).

    Google Scholar 

  • Nakagome, Y., Bloom, A. D.: Satellite associations of D-group chromosomes in translocation carriers. J. med. Genet. 7, 371–373 (1970).

    Google Scholar 

  • Patil, S. R., Lubs, H. A.: Non-random association of human acrocentric chromosomes. Humangenetik 13, 157–159 (1971).

    Google Scholar 

  • Rocchi, A., de Capoa, A., Gigliani, F.:Double satellite: autoradiographic study of a chromosomal marker observed in two generations. Humangenetik 14, 6–12 (1971).

    Google Scholar 

  • Shaw, M. W., Craig, A. P., Ricciuti, F. C.: Random association of human acrocentric chromosomes. Amer. J. hum. Genet. 21, 513–515 (1969).

    Google Scholar 

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de Capoa, A., Rocchi, A. & Gigliani, F. Frequency of satellite association in individuals with structural abnormalities of nucleolus organiser region. Humangenetik 18, 111–115 (1973). https://doi.org/10.1007/BF00291477

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  • DOI: https://doi.org/10.1007/BF00291477

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