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Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family

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Summary

A family in which two homoduplicated C4 haplotypes (or supergenes) segregate is described. One haplotype C4F * 3 C4F *2.2 is composed of two C4F alleles and the other C4S * 5.1 C4S *1 of two C4S alleles. The C4F duplication haplotype is a partial inhibitor of the Rodgers antigen, and judged from our family and population material, it seems to be rather frequent and associated with HLAB *35, Bf * F, and HLAD/DR *1. The C4S duplication haplotype is Rg(a-) and is not identified in individuals without another S, Ch(a+) variant.

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Authors and Affiliations

  1. Institute of Human Genetics, University of Aarhus, DK-8000, Aarhus C, Denmark

    G. Bruun-Petersen

  2. Tissue Typing Laboratory, University of Aarhus, DK-8000, Aarhus C, Denmark

    Lars U. Lamm

  3. Tissue Typing Laboratory, State University Hospital, DK-2200, Copenhagen N, Denmark

    Bodil K. Jacobsen & Tom Kristensen

Authors
  1. G. Bruun-Petersen
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  2. Lars U. Lamm
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  3. Bodil K. Jacobsen
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  4. Tom Kristensen
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Additional information

This work was supported by grant No 12-1727 from the Danish Medical Research Council

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Bruun-Petersen, G., Lamm, L.U., Jacobsen, B.K. et al. Genetics of complement C4. Two homoduplication haplotypes C4S C4S and C4F C4F in a family. Hum Genet 61, 36–38 (1982). https://doi.org/10.1007/BF00291328

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  • DOI: https://doi.org/10.1007/BF00291328

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