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Evidence for a ‘silent allele’ GLO 0 at the glyoxalase I locus

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Summary

In a three-generation family, the segregation of an apparent silent allele at the GLO I locus in association with the rare HLA haplotype ‘AW30-CW4-BW35’ was observed in four members. In two cases the assumption of homozygosity at the GLO locus would lead to mother-child exclusions. Phenotypically, the GLO activity in the GLO 0 carriers is clearly diminished.

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References

  • Harris, H., Hopkinson, D. A.: Handbook of enzyme electrophoresis in human genetics. Amsterdam-Oxford: North Holland 1976

    Google Scholar 

  • Kömpf, J., Bissbort, S., Ritter, H.: Polymorphism of red cell glyoxalase I (EC 4.4.1.5). A new genetic marker in man. Humangenetik 27, 141–143 (1975)

    Google Scholar 

  • Kömpf, J., Bissbort, F., Schunter, F., Wernet, P.: Map order of the linkage group GLO-Bf-HLA-A-PGM3 on human chromosome 6. Scand. J. Immunol. 6, 455–458 (1977)

    Google Scholar 

  • Kühnl, P., Schwabenland, R., Spielmann, W.: Investigations on the polymorphism of glyoxalase I (EC 4.4.1.5) in the population of Hessen, Germany. Hum. Genet. 38, 99–106 (1977)

    Google Scholar 

  • Martin, W., Ott, A.: Glyoxalase I: Darstellung in der Agarosegel-Dünnschicht-Elektrophorese und Genfrequenzen in Berlin (West). Tagungsband der 6. Internationalen Tagung der Gesellschaft für forensische Blutgruppenkunde e.V., Innsbruck, 1975, pp. 439–444 (1977)

  • Olaisen, B., Gedde-Dahl, T., Jr., Thorsby, E.: Localization of the human GLO gene locus. Hum. Genet. 32, 301–304 (1976)

    Google Scholar 

  • Mayr, W. R., Mayr, D., Kömpf, J., Bissbort, S., Ritter, H.: Possible linkage of HLA and GLO. Hum. Genet. 31, 241–242 (1976)

    Google Scholar 

  • Rittner, Ch.: Forensische Serologie. In: Gerichtliche Medizin, 2nd ed., B. Mueller, ed. Berlin-Heidelberg-New York: Springer 1975

    Google Scholar 

  • Rittner, Ch.: Genetic loci of components of the classical and alternate pathway of complement activation: A new dimension of the immunogenetic linkage group (HLA) on chromosome 6 in man. Hum. Genet. 35, 1–20 (1976)

    Google Scholar 

  • Weitkamp, L.: Linkage of GLO with HLA and Bf. Effect of population and sex on recombination frequency. Tissue Antigens 7, 273–280 (1976)

    Google Scholar 

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Authors and Affiliations

  1. Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, D-5300, Bonn

    Ch. Rittner & W. Weber

  2. Institute for Blood Group Research, Olpener Straße 110, D-5000, Cologne, Federal Republic of Germany

    Ch. Rittner & W. Weber

Authors
  1. Ch. Rittner
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  2. W. Weber
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Additional information

With rechnical assistance of Mrs. C. Walter and Mrs. M. Mueller

Supported by the Deutsche Forschungsgemeinschaft (Ri 164/12)

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Rittner, C., Weber, W. Evidence for a ‘silent allele’ GLO 0 at the glyoxalase I locus. Hum Genet 42, 315–318 (1978). https://doi.org/10.1007/BF00291312

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  • DOI: https://doi.org/10.1007/BF00291312

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