Abstract
Anhidrotic ectodermal dysplasia in an inbred kindred was observed in three sisters and three first cousins. This was interpreted as presumptive evidence for autosomal recessive inheritance and it is suggested that in addition to its known genes, anhidrotic ectodermal dysplasia occasionally may be caused by an autosomal recessive gene.
Similar content being viewed by others
References
Bernard, R., F. Giraud, M. Rouby, and M. Hartung: A propos de sept observations de dysplasie ectodermique. Arch. franç. Pediat. 20, 1051 (1963).
Datovo, L., e L. Levi: Rilievi sulla displasia ectodermica congenita. G. ital. Derm. 98, 526 (1957).
Drieux, H., M. Priouzeau, G. Thiéry et M. L. Priouzeau: Hypotrichose congénitale avec anodontie, acérie et macroglossie chez le veau. Rec. Méd. vét. 126, 385 (1950).
Hartwell, S. W., K. Pickrell, and G. Quinn: Congenital anhidrotic ectodermal dysplasia. Report of two cases. Clin. Pediat. (Phila.) 4, 383 (1965).
Kaalund-Jørgensen, O., and J. F. Christensen: Congenital ectodermal dysplasia of the anidrotic type. Acta derm.-venereol. (Stockh.) 22, 1 (1941).
Klein, D.: Une famille alsacienne de dysplasie ectodermique. J. Génét. hum. 3, 210 (1954).
Kuske, H.: Anhidrosis hypotrichotica mit Hypodontie. Dermatologica (Basel) 92, 303 (1946).
Laberge, C.: Prospectus for genetic studies on the French Canadians, with preliminary data on blood groups and consanguinity. Bull. Johns Hopk. Hosp. 118, 52 (1966).
McDonald, R. E.: Anodontia in hereditary ectodermal dysplasia. J. Hered. 40, 95 (1949).
McKusick, V. A.: On the X Chromosome of man. Baltimore: Waverly Press 1964.
—, J. A. Hostetler, and J. A. Egeland: Genetic studies of the Amish. Background and potentialities. Bull. Johns Hopk. Hosp. 115, 203 (1964).
Ohno, S.: A phylogenetic view of the X-chromosome in man. Ann. Génét. 8, 3 (1965).
Perabo, F., J. Velasco u. A. Prader: Ektodermale Dysplasie vom anhidrotischen Typus. Helv. paediat. Acta 11, 604 (1956).
Šalamon, T.: Die kongenitalen Hypotrichosen mit assoziierten Symptomen (Hypotrichoses associées, nach Touraine). In: Handbuch der Haut- und Geschlechtskrankheiten. Ergänzungswerk, Bd. VII: Vererbung von Hautkrankheiten. S. 385. Herausgegeben von H. A. Gottron u. U. W. Schnyder. Berlin-Heidelberg-New York: Springer 1966.
Schull, W. J., and J. V. Neel: The effects of inbreeding on Japanese children. New York: Harper and Row 1965.
Scriver, C. R., C. C. Solomons, E. Davies, M. Williams, and J. Bolton: A molecular abnormality of keratin in ectodermal dysplasia. Abstr., Soc. Ped. Res. Philadelphia, May 4–6, 1965.
Singh, A., S. S. Jolly, and S. Kaur: Hereditary ectodermal dysplasia. Brit. J. Derm. 74, 34 (1962).
Upshaw, B. Y., and H. Montgomery: Hereditary anhidrotic ectodermal dysplasia. Arch. Derm. Syph. (Chic.) 60, 1170 (1949).
Vogel, F., u. H. Dorn: Krankheiten der Haut und ihrer Anhangsgebilde. In: Humangenetik, Ein kurzes Handb., Herausgeber: P. E. Becker), Bd. IV, S. 346. Stuttgart: Thieme 1964.
Weech, A. A.: Hereditary ectodermal dysplasia (congenital ectodermal defect): A report of two cases. Amer. J. Dis. Child. 37, 766 (1929).
Keer, C. B., R. S. Wells, and K. E. Cooper: Gene effect in carriers of anhidrotic ectodermal dysplasia. J. med. Genet. 3, 169 (1966).
Author information
Authors and Affiliations
Additional information
This investigation was supported by Public Health Service Research Grant No. FR 00123, from GCRC-DRFR and by a Fellowship in Pediatric Teratology of the Children's Hospital Research Foundation, Cincinnati.
Rights and permissions
About this article
Cite this article
Passarge, E., Nuzum, C.T. & Schubert, W.K. Anhidrotic ectodermal dysplasia as autosomal recessive trait in an inbred kindred. Hum Genet 3, 181–185 (1966). https://doi.org/10.1007/BF00291298
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00291298