Abstract
Red cell acid phosphatase phenotypes were determined in 401 unrelated persons from Southwestern Germany. The frequencies of genes Pa, Pb and Pc were estimated to be p=0.328, q=0.630 and r=0.042.
Experiences in 101 cases of disputed paternity with 151 men involved are reported. 22 men could be excluded from paternity on the basis of red cell acid phosphatase phenotypes.
In all 140 mother-child-combinations tested the distribution of red cell acid phosphatase variants was compatible with the genetic model suggested by Hopkinson et al.
Usefulness of the system in forensic cases of disputed paternity is discussed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature
Hopkinson, D. A., H. Harris, and N. Spencer: Red cell acid phosphatase variants: a new human polymorphism. Nature (Lond.) 199, 969 (1963).
—: Genetical studies on human red cell acid phosphatase. American J. hum. Genet. 16, 141 (1964).
Harris, H.: Personal communication; cit. by L. Lai et al.
Lai, L., S. Nevo, and A. G. Steinberg: Acid phosphatase of human red cells: Predicted phenotype conforms to a genetic hypothesis. Science 145, 1187 (1964).
Prokop, O.: Neue Ergebnisse auf dem Gebiet der Blut- und Serumgruppen. Vortrag Tgg. Dtsch. Gesellsch. f. Gerichtl. und Soz. Med., Freiburg/Br. 7. 10. 1966; Personal communication.
Radam, G., u. H. Strauch: Populationsgenetik der sauren Erythrocytenphosphatase. Humangenetik 2, 378 (1966).
Author information
Authors and Affiliations
Additional information
Data contained in this paper will also constitute part of the thesis of cand. med. Karl-Henning Lichte.
Rights and permissions
About this article
Cite this article
Fuhrmann, W., Lichte, KH. Human red cell acid phosphatase polymorphism. Hum Genet 3, 121–126 (1966). https://doi.org/10.1007/BF00291293
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00291293