Summary
The correlation found by Moustacchi (1987) between cellular response to a crosslinking challenge and genetic heterogeneity in Fanconi's anaemia is confirmed for an earlier set of complementation groups (Zakrzewski and Sperling 1980). This allows the matching of the two independently established complementation groupings and better characterization of their DNA repair-related biochemical properties.
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References
Coquerelle TM, Weibezahn KF (1981) Rejoining of DNA double-strand breaks in human fibroblasts and its impairment in one Ataxia telangiectasia and two Fanconi strains. J Suprastruc Cell Biochem 17:369–376
Creissen D, Shall S (1982) Regulation of DNA ligase activity by poly(ADP-ribose). Nature 296:271–272
Digweed M, Zakrzewski-Lüdcke S, Sperling K (1987) Complementation studies in Fanconi's anaemia using cell fusion and microinjection of mRNA. In: Schroeder-Kurth TM, Obe G (eds) Fanconi's anaemia: clinical and experimental aspects. Springer, Berlin Heidelberg New York (in press)
Duckworth-Rysiecki G, Cornish K, Clarke CA, Buchwald M (1985) Identification of two complementation groups in Fanconi anemia. Somatic Cell Mol Genet 11:35–41
Fujiwara Y, Tatsumi M, Sasaki MS (1977) Cross-link repair in human cells and its possible defect in Fanconi's anemia cells. J Mol Biol 113:635–649
Gök MM, Wunder E (1987) Microinjection of normal cell extracts into Fanconi anemia fibroblasts corrects defective scheduled DNA synthesis recovery after 8-methoxypsoralen plus UVA treatment. Hum Genet 75:350–355
Gruenert DC, Cleaver J (1985) Repair of Psoralen-induced cross-links and monoadducts in normal and repair deficient human fibroblasts. Cancer Res 45:5399–5404
Hirsch-Kaufmann M, Schweiger M, Wagner EF, Sperling K (1978) Deficiency of DNA ligase activity in Fanconi's anemia. Hum Genet 45:25–32
Kaye J, Smith CA, Hanawalt PC (1980) DNA repair in human cells containing photoadducts of 8-methoxypsoralen or angelicin. Cancer Res 40:696–702
Klocker H, Auer B, Hirsch-Kaufmann M, Altmann H, Burtscher HJ, Schweiger M (1983) DNA repair dependent NAD+ metabolism is impaired in cells from patients with Fanconi's anemia. EMBO J 2:303–307
Klocker H, Burtscher HJ, Auer B, Hirsch-Kaufmann M, Schweiger M (1985) Fibroblasts from patients with Fanconi's anemia are not deficient in excision of thymine dimer. Eur J Cell Biol 37:240–242
Kunze J (1980) Estren-Dameshek-Anämie mit myelomonocytärer Leukämie (Subtyp der Fanconi-Anämie?) In: Tolksdorf M, Spranger J (eds) Klinische Genetik in der Pädiatrie. Thieme, Stuttgart, pp 213–214
Moustacchi E, Diatloff-Zito C (1985) DNA semi-conservative synthesis in normal and Fanconi anemia fibroblasts following treatment with 8-methoxypsoralen and near UV-light or with X-rays. Hum Genet 70:236–242
Moustacchi E, Papadopoulo D, Diatloff-Zito C, Buchwald M (1987) Two complementation groups of Fanconi's anemia differ in their phenotypic response to a DNA-crosslinking treatment. Hum Genet 75:45–47
Poll EHA, Arwert F, Kortbeek HT, Eriksson AW (1984) Fanconi anaemia cells are not uniformly deficient in unhooking of DNA interstrand crosslinks, induced by mitomycin C or 8-methoxypsoralen plus UVA. Hum Genet 68:228–234
Schroeder TM, Tilgen D, Krüger J, Vogel F (1976a) Formal genetics of Fanconi's anemia. Hum Genet 32:257–288
Schroeder TM, Drings P, Beiler P, Buchinger G (1976b) Clinical and cytogenetic observations during a six year period in an adult with Fanconi's anemia. Blut 34:119–132
Schweiger M, Auer B, Burtscher HJ, Hirsch-Kaufmann M, Klocker H, Schneider R (1986) DNA Repair in human cells: biochemistry of the hereditary diseases Fanconi's anaemia and Cockayne syndrome. Biol Chem Hoppe-Seyler 367:1185–1195
Sperling K, Wegner RD, Riehm H, Obe G (1975) Frequency and distribution of sister chromatid exchanges in a case of Fanconi's anemia. Humangenetik 27:227–230
Weksberg R, Buchwald M, Sargent P, Thompson MW, Siminovitch L (1979) Specific cellular defects in patients with Fanconi anemia. J Cell Physiol 101:311–324
Yoshida MC (1982) The absence of genetic heterogeneity in Fanconi's anemia in five patients demonstrated by somatic cell hybridization. Cytogenet Cell Genet 32:329–330
Zakrzewski S, Sperling K (1980) Genetic hetrogeneity of Fanconi's anemia demonstrated by somatic cell hybrids. Hum Genet 56:81–84
Zakrzewski S, Sperling K (1982) Analysis of heterogeneity in Fanconi's anemia patients of different ethnic origin. Hum Genet 62:321–323
Zakrzewski S, Koch M, Sperling K (1983) Complementation studies between Fanconi's anemia cells with different repair characteristics. Hum Genet 64:55–57
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Digweed, M., Zakrzewski-Lüdcke, S. & Sperling, K. Fanconi's anaemia: correlation of genetic complementation group with psoralen/UVA response. Hum Genet 78, 51–54 (1988). https://doi.org/10.1007/BF00291234
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DOI: https://doi.org/10.1007/BF00291234