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Unterschiedliche fluorescenz der beiden homologen chromosomen Nr. 3 beim menschen

Difference in fluorescence of the homologe chromosomes No. 3 in man

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Summary

After staining human chromosomes with quinacrine the chromosome No. 3 frequently shows a strongly fluorescent spot on the long arm near the centromere. This spot was found in 59% of the chromosomes No. 3 of 50 normal persons. It may be present either in both, only in one, or in none of the chromosomes No. 3 in the diploid chromosome set. One of these behaviours is constantly found in all diploid cells obtained from one individual. Tetraploid cells behave accordingly. From these observations and from the frequency of occurrence in a normal population it may be deduced that this body represents an inborn variation of chromosome No. 3 that can be absent or present in a heterozygous or homozygous state in different individuals.

Zusammenfassung

Nach Atebrinfärbung menschlicher Chromosomen zeigen insgesamt 59% der untersuchten Chromosomen Nr. 3 von 50 Versuchspersonen eine stark fluorescierende Stelle im langen Arm nahe dem Centromer. Das Verhalten der Chromosomen Nr. 3 ist für ein Individuum in allen Zellen konstant. In diploiden Zellen verschiedener Personen enthalten entweder beide, nur eines oder keines der Chromosomen Nr. 3 diese leuchtende Stelle. Tetraploide Zellen verhalten sich entsprechend: entweder alle 4, 2 oder keines der Chromosomen Nr. 3 zeigen die leuchtende Stelle. Daraus und aus der Häufigkeitsverteilung der Kombinationen in einer normalen Bevölkerungsgruppe könnte geschlossen werden, daß es sich bei der fluorescierenden Stelle um eine erbliche Chromosomenvariation handelt, die homozygot positiv, heterozygot oder homozygot negativ vorkommen kann.

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Authors and Affiliations

  1. Histologisch-Embryologisches Institut der Universität Wien, Wien, Österreich

    W. Schnedl

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  1. W. Schnedl
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Schnedl, W. Unterschiedliche fluorescenz der beiden homologen chromosomen Nr. 3 beim menschen. Hum Genet 12, 59–63 (1971). https://doi.org/10.1007/BF00291034

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  • DOI: https://doi.org/10.1007/BF00291034

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